Recent data suggest that the interaction between gastroesophageal reflux disease (GERD)
and eosinophilic esophagitis can be complex, and that the notion of establishing a clear …

Heartburn is the most common and characteristic symptom of gastroesophageal reflux
disease. It ultimately results from contact of refluxed gastric acid with nociceptors within the …

Methods: All consecutive patients with a confirmed diagnosis of EoE from 1988 to 2013
treated at University of South Florida were included. Patients were grouped into …

Gastroesophageal reflux disease (GERD) is one of the most common problems in clinical
practice today. It is widely believed that functional and structural abnormalities of the …

Background & Aims: Gastroesophageal reflux disease is a condition frequently associated
with esophagitis and motor abnormalities. Recent evidence suggests that proinflammatory …

Genomic sequencing, bioinformatics, and initial speciation (eg, relative abundance) of the
commensal microbiome have revolutionized the way we think about the “human” body in …

NOX5 is a ROS-generating NADPH oxidase which contains an N-terminal EF-hand region
and can be activated by cytosolic Ca2+ elevations. However the C-terminal region of NOX5 …

The etiology of esophageal mucosal injury is complex, since it may involve the reflux of
gastric acid, bile acid, and pancreatic juice, external factors such as drugs and alcohol, or …

The pathophysiology of gastroesophageal reflux disease remains incompletely understood.
Its hallmark symptom is “heartburn” and, on the basis of endoscopy, those with heartburn are …

Over the past three decades, the detection of oesophageal mucosal eosinophils has
transitioned from a biomarker of GERD to a diagnostic criterion for eosinophilic oesophagitis …