Cardiomyocytes exit the cell cycle and become terminally differentiated soon after birth.
Therefore, in the adult heart, instead of an increase in cardiomyocyte number, individual …

Patients with diabetes mellitus have> 2× the risk for developing heart failure (HF; HF with
reduced ejection fraction and HF with preserved ejection fraction). Cardiovascular …

The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

Owing to the prevalence and high mortality rates of cardiac diseases, a more detailed
characterization of the human heart is necessary; however, this has been largely impeded …

Rationale: Accurate knowledge of the cellular composition of the heart is essential to fully
understand the changes that occur during pathogenesis and to devise strategies for tissue …

Cardiac fibrosis is defined as the imbalance of extracellular matrix (ECM) production and
degradation, thus contributing to cardiac dysfunction in many cardiac pathophysiologic …

Angiotensin Converting Enzyme2 is the cell surface binding site for the coronavirus SARS‐
CoV‐2, which causes COVID‐19. We propose that an imbalance in the action of ACE1‐and …

Cardiac remodeling is defined as a group of molecular, cellular and interstitial changes that
manifest clinically as changes in size, mass, geometry and function of the heart after injury …

Both type 1 and type 2 diabetes are associated with cardiac fibrosis that may reduce
myocardial compliance, contribute to the pathogenesis of heart failure, and trigger …

Left ventricular hypertrophy is a leading risk factor for cardiovascular morbidity and mortality.
Although reverse ventricular remodelling was long thought to be irreversible, evidence from …