Advances in anion transport and supramolecular medicinal chemistry

JT Davis, PA Gale, R Quesada - Chemical Society Reviews, 2020 - pubs.rsc.org
Advances in anion transport by synthetic supramolecular systems are discussed in this
article. Developments in the design of discrete molecular carriers for anions and …

Supramolecular chemistry in lipid bilayer membranes

LE Bickerton, TG Johnson, A Kerckhoffs… - Chemical Science, 2021 - pubs.rsc.org
Lipid bilayer membranes form compartments requisite for life. Interfacing supramolecular
systems, including receptors, catalysts, signal transducers and ion transporters, enables the …

A benzohydrazide-based artificial ion channel that modulates chloride ion concentration in cancer cells and induces apoptosis by disruption of autophagy

A Mondal, SN Save, S Sarkar, D Mondal… - Journal of the …, 2023 - ACS Publications
Fluctuations in the intracellular chloride ion concentration, mediated by synthetic ion
transporters, have been known to induce cytotoxicity in cells by disrupting ionic …

Photo‐and Redox‐Regulated Transmembrane Ion Transporters

M Ahmad, SA Gartland… - Angewandte Chemie …, 2023 - Wiley Online Library
Synthetic supramolecular ion transporters find applications as potential therapeutics and as
tools for engineering functional membranes. Stimuli‐responsive systems enable external …

A glutathione activatable ion channel induces apoptosis in cancer cells by depleting intracellular glutathione levels

JA Malla, RM Umesh, S Yousf, S Mane… - Angewandte Chemie …, 2020 - Wiley Online Library
Cancer cells use elevated glutathione (GSH) levels as an inner line of defense to evade
apoptosis and develop drug resistance. In this study, we describe a novel 2, 4 …

A comprehensive review on steroidal bioconjugates as promising leads in drug discovery

R Bansal, A Suryan - ACS bio & med Chem Au, 2022 - ACS Publications
Ever increasing unmet medical requirements of the human race and the continuous fight for
survival against variety of diseases give birth to novel molecules through research. As …

Progress and prospects toward supramolecular bioactive ion transporters

A Mondal, M Ahmad, D Mondal… - Chemical …, 2023 - pubs.rsc.org
The majority of cellular physiological processes depend on natural ion channels, which are
pore-forming membrane-embedded proteins that let ions flow across the cell membranes …

A sandwich azobenzene–diamide dimer for photoregulated chloride transport

M Ahmad, S Metya, A Das… - Chemistry–A European …, 2020 - Wiley Online Library
There has been a tremendous evolution for artificial ion transport systems, especially gated
synthetic systems, which closely mimic their natural congeners. Herein, we demonstrate a …

Apoptosis-inducing activity of a fluorescent barrel-rosette M+/Cl− channel

JA Malla, RM Umesh, A Vijay, A Mukherjee… - Chemical …, 2020 - pubs.rsc.org
Synthetic transmembrane ion transport systems are emerging as new tools for anticancer
therapy. Here, a series of 2-hydroxy-N1, N3-diarylisophthalamide-based fluorescent ion …

NAD(P)H:Quinone Acceptor Oxidoreductase 1 (NQO1) Activatable Salicylamide H+/Cl Transporters

NJ Roy, SN Save, VK Sharma… - … A European Journal, 2023 - Wiley Online Library
Abstract NAD (P) H: quinone acceptor oxidoreductase 1 (NQO1), a detoxifying enzyme
overexpressed in tumors, plays a key role in protecting cancer cells against oxidative stress …