Lipid bilayer membranes form compartments requisite for life. Interfacing supramolecular systems, including receptors, catalysts, signal transducers and ion transporters, enables the …
Fluctuations in the intracellular chloride ion concentration, mediated by synthetic ion transporters, have been known to induce cytotoxicity in cells by disrupting ionic …
M Ahmad, SA Gartland… - Angewandte Chemie …, 2023 - Wiley Online Library
Synthetic supramolecular ion transporters find applications as potential therapeutics and as tools for engineering functional membranes. Stimuli‐responsive systems enable external …
JA Malla, RM Umesh, S Yousf, S Mane… - Angewandte Chemie …, 2020 - Wiley Online Library
Cancer cells use elevated glutathione (GSH) levels as an inner line of defense to evade apoptosis and develop drug resistance. In this study, we describe a novel 2, 4 …
R Bansal, A Suryan - ACS bio & med Chem Au, 2022 - ACS Publications
Ever increasing unmet medical requirements of the human race and the continuous fight for survival against variety of diseases give birth to novel molecules through research. As …
The majority of cellular physiological processes depend on natural ion channels, which are pore-forming membrane-embedded proteins that let ions flow across the cell membranes …
M Ahmad, S Metya, A Das… - Chemistry–A European …, 2020 - Wiley Online Library
There has been a tremendous evolution for artificial ion transport systems, especially gated synthetic systems, which closely mimic their natural congeners. Herein, we demonstrate a …
Synthetic transmembrane ion transport systems are emerging as new tools for anticancer therapy. Here, a series of 2-hydroxy-N1, N3-diarylisophthalamide-based fluorescent ion …
NJ Roy, SN Save, VK Sharma… - … A European Journal, 2023 - Wiley Online Library
Abstract NAD (P) H: quinone acceptor oxidoreductase 1 (NQO1), a detoxifying enzyme overexpressed in tumors, plays a key role in protecting cancer cells against oxidative stress …