Guanine-rich DNA sequences can fold into four-stranded, noncanonical secondary
structures called G-quadruplexes (G4s). G4s were initially considered a structural curiosity …

Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear
chromosome ends. Because telomeres shorten progressively with each replication, they …

Humans are variously and continuously exposed to a wide range of different DNA-damaging
agents, some of which are classed as carcinogens. DNA damage can arise from exposure to …

Telomeres are DNA-protein complexes that cap and protect the ends of linear
chromosomes. In almost all species, telomeric DNA has a G/C strand bias, and the short …

DNA damage is the cause of numerous human pathologies including cancer, premature
aging, and chronic inflammatory conditions. The DNA damage response (DDR), in turn …

The excessive production of reactive oxygen species (ROS) can lead to single nucleic acid
base damage, DNA strand breakage, inter-and intra-strand cross-linking of nucleic acids …

Telomere integrity is essential for genome stability and it regulates cell proliferation and
tissue renewal. Several lines of evidence indicate that telomeres are particularly sensitive to …

Telomeres, also known as the “protective caps” of our chromosomes, shorten with each cell
cycle due to the end replication problem. This process, termed telomere attrition, is …

The role of non-duplex DNA, the guanine-quadruplex structure in particular, is becoming
widely appreciated. Increasing evidence in the last decade implicates quadruplexes in …

The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is well recognized
as a critical regulator of redox, metabolic, and protein homeostasis, as well as the regulation …