Parkinson's disease is a progressive neurodegenerative disorder. The classical motor
symptoms include resting tremors, bradykinesia, rigidity and postural instability and are …

Parkinson's disease (PD) is a neurodegenerative disorder that affects about 1.5% of the
global population over 65 years of age. A hallmark feature of PD is the degeneration of the …

Parkinson disease (PD) is a complex neurodegenerative disorder with both motor and
nonmotor symptoms owing to a spreading process of neuronal loss in the brain. At present …

A major challenge in Parkinson disease (PD) will be to turn an emerging and expanding
pipeline of novel disease-modifying candidate compounds into therapeutics. Novel targets …

Parkinson's disease (PD) is a heterogenous disease with a varying age of onset, symptoms,
and rate of progression. This heterogeneity requires the use of a variety of animal models to …

Parkinson's disease (PD) is a complex disease, with genetics and environment contributing
to the disease onset. Recent studies of causative PD genes have confirmed the involvement …

Parkinson's disease is one of the most common neurodegenerative diseases. Animal
models have contributed a large part to our understanding and therapeutics developed for …

Numerous disorders of the central nervous system (CNS) are attributed to the selective
death of distinct neuronal cell populations. Interestingly, in many of these conditions, a …

Mitochondrial dysfunction is a common feature of many genetic disorders that target the
brain and cognition. However, the exact role these organelles play in the etiology of such …

Recessively inherited loss-of-function mutations in the PTEN-induced putative kinase 1
(Pink1), DJ-1 (Park7) and Parkin (Park2) genes are linked to familial cases of early-onset …