Age-associated B cells in autoimmune diseases

IC Mouat, E Goldberg, MS Horwitz - Cellular and Molecular Life Sciences, 2022 - Springer
Age-associated B cells (ABCs) are a transcriptionally and functionally unique B cell
population. In addition to arising with age and following infection, ABCs are expanded …

Genetics of SLE: mechanistic insights from monogenic disease and disease-associated variants

CG Vinuesa, N Shen, T Ware - Nature Reviews Nephrology, 2023 - nature.com
The past few years have provided important insights into the genetic architecture of systemic
autoimmunity through aggregation of findings from genome-wide association studies …

[HTML][HTML] Pan-cancer single-cell dissection reveals phenotypically distinct B cell subtypes

Y Yang, X Chen, J Pan, H Ning, Y Zhang, Y Bo, X Ren… - Cell, 2024 - cell.com
Characterizing the compositional and phenotypic characteristics of tumor-infiltrating B cells
(TIBs) is important for advancing our understanding of their role in cancer development …

The expansion of human T-bethighCD21low B cells is T cell dependent

B Keller, V Strohmeier, I Harder, S Unger… - Science …, 2021 - science.org
Accumulation of human CD21low B cells in peripheral blood is a hallmark of chronic
activation of the adaptive immune system in certain infections and autoimmune disorders …

Human T-bet governs the generation of a distinct subset of CD11chighCD21low B cells

R Yang, DT Avery, KJL Jackson, M Ogishi… - Science …, 2022 - science.org
High-level expression of the transcription factor T-bet characterizes a phenotypically distinct
murine B cell population known as “age-associated B cells”(ABCs). T-bet–deficient mice …

Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice

KM Nickerson, S Smita, KB Hoehn… - Journal of Experimental …, 2023 - rupress.org
Age-associated B cells (ABCs) are formed under inflammatory conditions and are
considered a type of memory B cell (MBC) expressing the transcription factor T-bet. In SLE …

Roles of follicular helper and regulatory T cells in allergic diseases and allergen immunotherapy

Y Yao, CL Chen, D Yu, Z Liu - Allergy, 2021 - Wiley Online Library
Allergic diseases are characterized by overactive type 2 immune responses to allergens and
immunoglobulin E (IgE)‐mediated hypersensitivity. Emerging evidence suggests that …

Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice

E Ricker, M Manni, D Flores-Castro, D Jenkins… - Nature …, 2021 - nature.com
Differences in immune responses to viruses and autoimmune diseases such as systemic
lupus erythematosus (SLE) can show sexual dimorphism. Age-associated B cells (ABC) are …

Zeb2 drives the formation of CD11c+ atypical B cells to sustain germinal centers that control persistent infection

X Gao, Q Shen, JA Roco, B Dalton, K Frith… - Science …, 2024 - science.org
CD11c+ atypical B cells (ABCs) are an alternative memory B cell lineage associated with
immunization, infection, and autoimmunity. However, the factors that drive the transcriptional …

Molecular mechanisms controlling age‐associated B cells in autoimmunity

S Phalke, J Rivera‐Correa, D Jenkins… - Immunological …, 2022 - Wiley Online Library
Age‐associated B cells (ABCs) have emerged as critical components of immune responses.
Their inappropriate expansion and differentiation have increasingly been linked to the …