GABAergic signaling beyond synapses: an emerging target for cancer therapy

D Huang, PB Alexander, QJ Li, XF Wang - Trends in cell biology, 2023 - cell.com
Traditionally, γ-aminobutyric acid (GABA) is best known for its role as a primary inhibitory
neurotransmitter reducing neuronal excitability in the mammalian central nervous system …

GABAergic signaling by cells of the immune system: more the rule than the exception

AK Bhandage, A Barragan - Cellular and Molecular Life Sciences, 2021 - Springer
Gamma-aminobutyric acid (GABA) is best known as an essential neurotransmitter in the
evolved central nervous system (CNS) of vertebrates. However, GABA antedates the …

GABRP regulates chemokine signalling, macrophage recruitment and tumour progression in pancreatic cancer through tuning KCNN4-mediated Ca2+ signalling in a …

SH Jiang, LL Zhu, M Zhang, RK Li, Q Yang, JY Yan… - Gut, 2019 - gut.bmj.com
Background and aims Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of
cancer-related death worldwide. Neurotransmitter-initiated signalling pathway is profoundly …

[HTML][HTML] GABAergic signaling as a potential therapeutic target in cancers

Y Yang, L Ren, W Li, Y Zhang, S Zhang, B Ge… - Biomedicine & …, 2023 - Elsevier
GABA is the most common inhibitory neurotransmitter in the vertebrate central nervous
system. Synthesized by glutamic acid decarboxylase, GABA could specifically bind with two …

[HTML][HTML] The molecular mechanism of chronic stress affecting the occurrence and development of breast cancer and potential drug therapy

H Liu, C Li, B Cao, Y Jiang, L Han, R Xu, J Lin… - Translational …, 2022 - Elsevier
According to the 2020 data released by the International Agency for Research on Cancer,
breast cancer has surpassed lung cancer as the world's most newly diagnosed first-time …

A motogenic GABAergic system of mononuclear phagocytes facilitates dissemination of coccidian parasites

AK Bhandage, GC Olivera, S Kanatani, E Thompson… - Elife, 2020 - elifesciences.org
Gamma-aminobutyric acid (GABA) serves diverse biological functions in prokaryotes and
eukaryotes, including neurotransmission in vertebrates. Yet, the role of GABA in the immune …

Endorsement of TNBC biomarkers in precision therapy by nanotechnology

A Chaudhuri, DN Kumar, D Dehari, R Patil, S Singh… - Cancers, 2023 - mdpi.com
Simple Summary Triple-negative breast cancer (TNBC), the most aggressive and
heterogenous type of cancer, lacks the expression of hormones like estrogen, progesterone …

Invadopodia are chemosensing protrusions that guide cancer cell extravasation to promote brain tropism in metastasis

KC Williams, MA Cepeda, S Javed, K Searle… - Oncogene, 2019 - nature.com
Invadopodia are cell protrusions that mediate cancer cell extravasation but the
microenvironmental cues and signaling factors that induce invadopodia formation during …

[HTML][HTML] The delta subunit of the GABAA receptor is necessary for the GPT2-promoted breast cancer metastasis

N Li, X Xu, D Liu, J Gao, Y Gao, X Wu, H Sheng, Q Li… - Theranostics, 2023 - ncbi.nlm.nih.gov
Objectives: Glutamic pyruvate transaminase (GPT2) catalyzes the reversible transamination
between alanine and α-ketoglutarate (α-KG) to generate pyruvate and glutamate during …

Therapeutically leveraging GABAA receptors in cancer

D Bhattacharya, VS Gawali, L Kallay… - Experimental …, 2021 - journals.sagepub.com
γ-aminobutyric acid or GABA is an amino acid that functionally acts as a neurotransmitter
and is critical to neurotransmission. GABA is also a metabolite in the Krebs cycle. It is …