The mammalian HSP90 family of proteins is a cluster of highly conserved molecules that are
involved in myriad cellular processes. Their distribution in various cellular compartments …

Members of the Hsp90 molecular chaperone family are found in the cytosol, ER,
mitochondria and chloroplasts of eukaryotic cells, as well as in bacteria. These diverse …

Abstract The Hsp90 family proteins Hsp90, Grp94, and TRAP1 are present in the cell
cytoplasm, endoplasmic reticulum, and mitochondria, respectively; all play important roles in …

Tumour cells have long been considered defective in mitochondrial respiration and mostly
dependent on glycolytic metabolism. However, this assumption is currently challenged by …

Protein folding quality control does not occur randomly in cells, but requires the action of
specialized molecular chaperones compartmentalized in subcellular microenvironments …

Mitochondria can receive, integrate, and transmit a variety of signals to shape many
biochemical activities of the cell. In the process of tumor onset and growth, mitochondria …

Heat shock protein 90 (HSP90) molecular chaperones are a family of ubiquitous proteins
participating in several cellular functions through the regulation of folding and/or assembly of …

Aging is characterized by progressive decay of biological systems and although it is not
considered a disease, it is one of the main risk factors for chronic diseases and many types …

Functional Proteomics aims to the identification of in vivo protein-protein interaction (PPI) in
order to piece together protein complexes, and therefore, cell pathways involved in …

Mitochondria are key regulators of cell survival and are involved in a plethora of
mechanisms, such as metabolism, Ca2+ signaling, reactive oxygen species (ROS) …