Extracellular vesicles as tools and targets in therapy for diseases

MA Kumar, SK Baba, HQ Sadida… - Signal transduction and …, 2024 - nature.com
Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the
extracellular space. They exhibit diverse sizes, contents, and surface markers and are …

Intestinal microbiota influences non-intestinal related autoimmune diseases

MC Opazo, EM Ortega-Rocha… - Frontiers in …, 2018 - frontiersin.org
The human body is colonized by millions of microorganisms named microbiota that interact
with our tissues in a cooperative and non-pathogenic manner. These microorganisms are …

[HTML][HTML] Role of microbiota short-chain fatty acids in the pathogenesis of autoimmune diseases

A Rasouli-Saravani, K Jahankhani, S Moradi… - Biomedicine & …, 2023 - Elsevier
There is emerging evidence that microbiota and its metabolites play an important role in
helath and diseases. In this regard, gut microbiota has been found as a crucial component …

[HTML][HTML] Mesenchymal stem cell transplantation alleviates experimental Sjögren's syndrome through IFN-β/IL-27 signaling axis

G Yao, J Qi, J Liang, B Shi, W Chen, W Li, X Tang… - Theranostics, 2019 - ncbi.nlm.nih.gov
Rationale: Although mesenchymal stem cell (MSC) transplantation has been proved to be
an effective therapeutic approach to treat experimental Sjögren's syndrome (SS), the …

Role of extracellular vesicles in autoimmune pathogenesis

WC Wu, SJ Song, Y Zhang, X Li - Frontiers in immunology, 2020 - frontiersin.org
Autoimmune diseases are conditions that emerge from abnormal immune responses to
natural parts of the body. Extracellular vesicles (EVs) are membranous structures found in …

The mast cell–B cell axis in lung vascular remodeling and pulmonary hypertension

S Breitling, Z Hui, D Zabini, Y Hu… - … of Physiology-Lung …, 2017 - journals.physiology.org
Over past years, a critical role for the immune system and, in particular, for mast cells in the
pathogenesis of pulmonary hypertension (PH) has emerged. However, the way in which …

Diverse roles of the nucleic acid‐binding protein KHSRP in cell differentiation and disease

P Briata, D Bordo, M Puppo, F Gorlero… - Wiley …, 2016 - Wiley Online Library
The single‐stranded nucleic acid‐binding protein KHSRP (KH‐type splicing regulatory
protein) modulates RNA life and gene expression at various levels. KHSRP controls …

The role of dietary sodium intake on the modulation of T helper 17 cells and regulatory T cells in patients with rheumatoid arthritis and systemic lupus erythematosus

R Scrivo, L Massaro, C Barbati, M Vomero… - PLoS …, 2017 - journals.plos.org
We aimed at investigating whether the frequency and function of T helper 17 (Th17) and
regulatory T cells (Treg) are affected by a restriction of dietary sodium intake in patients with …

Regulatory immune cells and functions in autoimmunity and transplantation immunology

G Papp, P Boros, B Nakken, P Szodoray, M Zeher - Autoimmunity reviews, 2017 - Elsevier
In physiological circumstances, various tolerogenic mechanisms support the protection of
self-structures during immune responses. However, quantitative and/or qualitative changes …

The pathogenic, therapeutic and diagnostic role of exosomal microRNA in the autoimmune diseases

R Mirzaei, F Zamani, M Hajibaba… - Journal of …, 2021 - Elsevier
Exosomes are a nano-vesicle surrounded by a bilipid layer that can release from almost all
cells and could be detected in tissues and biological liquids. These vesicles contain lipids …