The nuclear hormone receptor (NR) superfamily includes the orphan NR4A subgroup,
comprised of Nur77 (NR4A1), Nurr1 (NR4A2) and NOR-1 (NR4A3). These NRs are …

Numerous members of the nuclear hormone receptor (NR) superfamily have been
demonstrated to regulate metabolic function in a cell-and tissue-specific manner. This …

We have proposed the “glucolipotoxicity” hypothesis in which elevated free fatty acids
(FFAs) together with hyperglycemia are synergistic in causing islet β-cell damage because …

Glucotoxicity and lipotoxicity contribute to the impaired β-cell function observed in type 2
diabetes. Here we examine the effect of saturated and unsaturated fatty acids at different …

Aims/hypothesis MicroRNAs are key regulators of gene expression involved in health and
disease. The goal of our study was to investigate the global changes in beta cell microRNA …

Maintenance of body temperature is achieved partly by modulating lipolysis by a network of
complex regulatory mechanisms. Lipolysis is an integral part of the glycerolipid/free fatty …

The Nr4a family of nuclear hormone receptors is composed of three members—
Nr4a1/Nur77, Nr4a2/Nurr1 and Nr4a3/Nor1. While currently defined as ligandless, these …

Fatty acids (FAs) 1 are energy-rich molecules, which play important metabolic roles. They
are also an integral part of cells as membrane components, which can influence fluidity and …

Stearoyl-CoA desaturase (SCD) synthesizes oleate necessary for the biosynthesis of
triglycerides and other lipids. Mice with a targeted disruption of the SCD1 gene are deficient …

Pancreatic β-cell mitogenesis is increased by insulin-like growth factor I (IGF-I) in a glucose-
dependent manner. In this study it was found that alternative β-cell nutrient fuels to glucose …