Lipid phosphoinositides are master regulators of almost all aspects of a cell's life and death
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …

Phosphoinositide signaling lipids are crucial for eukaryotes and regulate many aspects of
cell function. These signaling molecules are difficult to study because they are extremely low …

Lipid phosphoinositides are master regulators of multiple cellular functions. Misregulation of
the activity of the lipid kinases that generate phosphoinositides is causative of human …

Phosphoinositide signaling lipids (PIPs) are key regulators of membrane identity and
trafficking. Of these, PI (3, 5) P2 is one of the least well-understood, despite key roles in …

Phosphoinositides (PIs) constitute a minor fraction of total cellular lipids in all eukaryotic
cells. They fulfill many important functions through interaction with a wide range of cellular …

Phosphoinositides are lipids that are present in the cytoplasmic leaflet of a cell's plasma and
internal membranes and play pivotal roles in the regulation of a wide variety of cellular …

Recent studies of the low abundant signaling lipid, phosphatidylinositol 3, 5‐bisphosphate
(PI (3, 5) P2), reveal an intriguingly diverse list of downstream pathways, the intertwined …

Glucose entry into muscle cells is precisely regulated by insulin, through recruitment of
GLUT4 (glucose transporter-4) to the membrane of muscle and fat cells. Work done over …

Proteins that make, consume, and bind to phosphoinositides are important for constitutive
membrane traffic. Different phosphoinositides are concentrated in different parts of the …

The dual specificity mammalian enzyme PIKfyve phosphorylates in vitro position d-5 in
phosphatidylinositol (PtdIns) and PtdIns 3-P, itself or exogenous protein substrates. Here we …