Studies on bacterial physiology are incomplete without knowledge of the signalling and
regulatory systems that a bacterium uses to sense and respond to its environment. Two …

Pseudomonas aeruginosa is an opportunistic pathogen and major cause of hospital-
acquired infections. The virulence of P. aeruginosa is largely determined by its …

PhoB is a response regulator protein that plays a key role in the PhoBR two-component
signal transduction system. In this study, we used transcriptome and proteomics techniques …

Two-component signal transduction systems (TCSs), consisting of a sensor histidine kinase
(HK) and a response regulator (RR), sense environmental stimuli and then modulate cellular …

Abstract The dipeptide D‐Ala‐D‐Ala is an essential component of peptidoglycan and the
target of vancomycin. Most Clostridioides difficile strains possess the vanG operon …

Bordetella species cause lower respiratory tract infections in mammals. B. pertussis and B.
bronchiseptica are the causative agents of whooping cough and kennel cough, respectively …

To be effective pathogens, bacteria must adapt to the microenvironments they infect within a
host. The respiratory tract can be broadly divided into two environments: the upper and …

Two-component systems (TCS) are a major means by which microorganisms interact with
their environments. In a typical TCS, a sensor kinase senses an environmental stimulus and …

COBRE Center of Biomedical Research Excellence DBD DNA-binding domain DOOR2
Database of prokaryotic operons version 2 EMSA Electrophoretic mobility shift assay FASTA …