The prevalence of diabetes is continuously increasing in the recent decades. Persistent
hyperglycemia, hyperinsulinemia and the subsequent oxidative stress result in diabetic …

Major depressive disorder is one of the most common mental illnesses as it affects more
than 350 million people globally. Major depressive disorder is etiologically complex and …

Highlights•Chronic drug use alters the epigenetic state of neurons and other cell types within
brain reward regions.•Epigenetic adaptations are correlated with addiction, but their causal …

Repeated cocaine use induces coordinated changes in gene expression that drive plasticity
in the nucleus accumbens (NAc), an important component of the brain's reward circuitry, and …

Depression is a recurring and life-threatening illness that affects up to 120 million people
worldwide. In the present study, we show that chronic social defeat stress, an ethologically …

Forkhead box class O 3a (FOXO3a) is a transcription factor that has emerged as being a
tumor suppressor and longevity factor. The precise regulation of FOXO3a transactivation of …

Obesity is frequently associated with impairments in the social domain, and stress at puberty
can lead to long-lasting changes in visceral fat deposition and in social behaviors. However …

Drug addiction involves long-term behavioral abnormalities that arise in response to
repeated exposure to drugs of abuse in vulnerable individuals. It is a multifactorial syndrome …

Transcription factors represent the point of convergence of multiple signaling pathways
within eukaryotic cells. Deregulated transcription factors contribute to the pathogenesis of a …

Abstract Changes in gene expression are involved in many brain functions. Epigenetic
processes modulate gene expression by histone modification and DNA methylation or RNA …