Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery
drive cell division. Growing evidence indicates that this machinery operates in a distinct …

Neural stem cells in the adult mammalian brain are the source of new neurons that
contribute to complex sensory and cognitive functions. Most adult neural stem cells are …

In the adult rodent brain, neural stem cells (NSCs) persist in the ventricular-subventricular
zone (V-SVZ) and the subgranular zone (SGZ), which are specialized niches in which young …

Adult somatic stem cells in various organs maintain homeostatic tissue regeneration and
enhance plasticity. Since its initial discovery five decades ago, investigations of adult …

A large population of neural stem/precursor cells (NSCs) persists in the ventricular–
subventricular zone (V-SVZ) located in the walls of the lateral brain ventricles. V-SVZ NSCs …

The ventricular-subventricular zone (V-SVZ), on the walls of the lateral ventricles, harbors
the largest neurogenic niche in the adult mouse brain. Previous work has shown that neural …

In the embryonic and adult brain, neural stem cells proliferate and give rise to neurons and
glia through highly regulated processes. Epigenetic mechanisms—including DNA and …

New neurons arise from quiescent adult neural progenitors throughout life in specific
regions of the mammalian brain. Little is known about the embryonic origin and …

The ventricular-subventricular zone (V-SVZ) harbors adult neural stem cells. V-SVZ neural
stem cells exhibit features of astrocytes, have a regional identity, and depending on their …

Somatic stem cells have been identified in multiple adult tissues. Whether self-renewal
occurs symmetrically or asymmetrically is key to understanding long-term stem cell …