Histone mutations in cancer
KN Espinoza Pereira, J Shan, JD Licht… - Biochemical Society …, 2023 - portlandpress.com
Genes encoding histone proteins are recurrently mutated in tumor samples, and these
mutations may impact nucleosome stability, histone post-translational modification, or …
mutations may impact nucleosome stability, histone post-translational modification, or …
[HTML][HTML] The cell-cycle choreography of H3 variants shapes the genome
K Delaney, N Weiss, G Almouzni - Molecular Cell, 2023 - cell.com
Histone variants provide versatility in the basic unit of chromatin, helping to define dynamic
landscapes and cell fates. Maintaining genome integrity is paramount for the cell, and it is …
landscapes and cell fates. Maintaining genome integrity is paramount for the cell, and it is …
[HTML][HTML] GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant
I Liu, GAV Cruzeiro, L Bjerke, RF Rogers, Y Grabovska… - Cancer cell, 2024 - cell.com
Diffuse hemispheric gliomas, H3G34R/V-mutant (DHG-H3G34), are lethal brain tumors
lacking targeted therapies. They originate from interneuronal precursors; however …
lacking targeted therapies. They originate from interneuronal precursors; however …
Immune landscape of oncohistone-mutant gliomas reveals diverse myeloid populations and tumor-promoting function
Histone H3-mutant gliomas are deadly brain tumors characterized by a dysregulated
epigenome and stalled differentiation. In contrast to the extensive datasets available on …
epigenome and stalled differentiation. In contrast to the extensive datasets available on …
[HTML][HTML] Impaired T3 uptake and action in MCT8-deficient cerebral organoids underlie Allan-Herndon-Dudley syndrome
Patients with mutations in the thyroid hormone (TH) cell transporter monocarboxylate
transporter 8 (MCT8) gene develop severe neuropsychomotor retardation known as Allan …
transporter 8 (MCT8) gene develop severe neuropsychomotor retardation known as Allan …
Histone variant H2BE enhances chromatin accessibility in neurons to promote synaptic gene expression and long-term memory
Histone proteins affect gene expression through multiple mechanisms, including through
exchange with histone variants. Recent findings link histone variants to neurological …
exchange with histone variants. Recent findings link histone variants to neurological …
[HTML][HTML] Histone methylation mediated by NSD1 is required for the establishment and maintenance of neuronal identities
Y Zheng, C Zhao, Q Song, L Xu, B Zhang, G Hu… - Cell Reports, 2023 - cell.com
Appropriate histone modifications emerge as essential cell fate regulators of neuronal
identities across neocortical areas and layers. Here we showed that NSD1, the …
identities across neocortical areas and layers. Here we showed that NSD1, the …
Uncovering a mammalian neural-specific poly (A) binding protein with unique properties
S Sharma, S Kajjo, Z Harra, B Hasaj… - Genes & …, 2023 - genesdev.cshlp.org
Abstract The mRNA 3′ poly (A) tail plays a critical role in regulating both mRNA translation
and turnover. It is bound by the cytoplasmic poly (A) binding protein (PABPC), an …
and turnover. It is bound by the cytoplasmic poly (A) binding protein (PABPC), an …
(B) On (e)-cohistones and the epigenetic alterations at the root of bone cancer
P Salomoni, AM Flanagan, L Cottone - Cell Death & Differentiation, 2023 - nature.com
Identification of mutations in histones in a number of human neoplasms and developmental
syndromes represents the most compelling evidence to date for a causal role of epigenetic …
syndromes represents the most compelling evidence to date for a causal role of epigenetic …
H3G34-mutant gliomas—a review of molecular pathogenesis and therapeutic options
The 2021 World Health Organization Classification of Tumors of the Central Nervous System
reflected advances in understanding of the roles of oncohistones in gliomagenesis with the …
reflected advances in understanding of the roles of oncohistones in gliomagenesis with the …