Leaky gut syndrome is a medical condition characterized by intestinal hyperpermeability.
Since the intestinal barrier is one of the essential components maintaining homeostasis …

Pharmacological treatment of growth hormone deficiency (GHD) in adults began in clinical
practice more than 20 years ago. Since then, a great volume of experience has been …

Non-pituitary growth hormone (npGH) expression is well established in extrapituitary
tissues, but an understanding of the physiological role of npGH remains rather limited. Pro …

Abstract interactions between growth hormone (GH), insulin-like growth factor-1 (iGF-1), and
the immune system are complex, bidirectional, but not fully explained. Current reviews …

Both the GH/IGF-1 axis and the gut microbiota independently play an important role in host
growth, metabolism, and intestinal homeostasis. Inversely, abnormalities in GH action and …

Growth hormone (GH) promotes body growth by binding with two GH receptors (GHRs) at
the cell surface. GHRs interact with Janus kinase, signal transducers, and transcription …

Inflammatory bowel diseases (IBD) are gastrointestinal tract pathologies of unknown
etiology; they have an alternating trend, with active and silent phases. IBD are classified in …

Impairment of growth is recognized as one of the most significant complications of
inflammatory bowel disease (IBD) in pediatric patients. The reported incidence of growth …

Inflammation, demyelination, and axonal damage to the central nervous system (CNS) are
the hallmarks of multiple sclerosis (MS) and its representative animal model, experimental …

Abstract Purpose of Review Canonical growth hormone (GH)-dependent signaling is
essential for growth and counterregulatory responses to hypoglycemia, but also may …