There are many pathways of endocytosis at the cell surface that apparently operate at the
same time. With the advent of new molecular genetic and imaging tools, an understanding of …

(Macro) autophagy is a bulk degradation process that mediates the clearance of long-lived
proteins and organelles. Autophagy is initiated by double-membraned structures, which …

▪ Abstract Sorting of transmembrane proteins to endosomes and lysosomes is mediated by
signals present within the cytosolic domains of the proteins. Most signals consist of short …

Attachment of ubiquitin or ubiquitin-like proteins (known as UBLs) to their targets through
multienzyme cascades is a central mechanism to modulate protein functions. This process is …

The two major cellular sites for membrane protein degradation are the proteasome and the
lysosome. Ubiquitin attachment is a sorting signal for both degradation routes. For lysosomal …

The sorting of proteins into the inner vesicles of multivesicular bodies is required for many
key cellular processes, which range from the downregulation of activated signalling …

▪ Abstract Ubiquitin regulates protein transport between membrane compartments by serving
as a sorting signal on protein cargo and by controlling the activity of trafficking machinery …

After endocytosis, some membrane proteins recycle from early endosomes to the plasma
membrane whereas others are transported to late endosomes and lysosomes for …

Organelles in the endocytic pathway are composed of a mosaic of structural and functional
regions. These regions consist, at least in part, of specialized protein–lipid domains within …

The use of antibody-drug conjugates (ADCs) as a therapeutic platform to treat cancer has
recently gained substantial momentum. This therapeutic modality has the potential to …