Revolutionizing our understanding of Parkinson's disease: Dr. Heinz Reichmann's pioneering research and future research direction

M Tanaka, L Vécsei - Journal of Neural Transmission, 2024 - Springer
Millions of individuals around the world are afflicted with Parkinson's disease (PD), a
prevalent and incapacitating neurodegenerative disorder. Dr. Reichmann, a distinguished …

Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man

M Gerlach, P Riederer - Journal of neural transmission, 1996 - Springer
Animal models are an important aid in experimental medical science because they enable
one to study the pathogenetic mechanisms and the therapeutic principles of treating the …

Mitochondrial dysfunction in Parkinson′ s disease

PC Keane, M Kurzawa, PG Blain… - Parkinson's …, 2011 - Wiley Online Library
Parkinson′ s disease (PD) is a progressive, neurodegenerative condition that has
increasingly been linked with mitochondrial dysfunction and inhibition of the electron …

Lewy bodies, iron, inflammation and neuromelanin: pathological aspects underlying Parkinson's disease

P Riederer, T Nagatsu, MBH Youdim, M Wulf… - Journal of Neural …, 2023 - Springer
Since the description of some peculiar symptoms by James Parkinson in 1817, attempts
have been made to define its cause or at least to enlighten the pathology of “Parkinson's …

The role of iron in neurodegeneration: prospects for pharmacotherapy of Parkinson's disease

KA Jellinger - Drugs & aging, 1999 - Springer
Although the aetiology of Parkinson's disease (PD) and related neurodegenerative
disorders is still unknown, recent evidence from human and experimental animal models …

Biochemical and pharmacological characterization of 1-trichloromethyl-1, 2, 3, 4-tetrahydro-β-carboline: a biologically relevant neurotoxin?

P Riederer, P Foley, G Bringmann, D Feineis… - European Journal of …, 2002 - Elsevier
Acute and long-term effects of exposure to reactive compounds as the result of
environmental pollution, workplace conditions or dietary intake are suspected to be involved …

Connecting the dots between mitochondrial dysfunction and Parkinson's disorder: Focus mitochondria-targeting therapeutic paradigm in mitigating the disease …

I Kaur, T Behl, A Sehgal, S Singh, N Sharma… - … Science and Pollution …, 2021 - Springer
Mitochondria are unique cell organelles, which exhibit multifactorial roles in numerous cell
physiological processes, significantly preserving the integrity of neural synaptic …

[HTML][HTML] Trichloroethylene and its metabolite TaClo lead to degeneration of substantia nigra dopaminergic neurones: Effects in wild type and human A30P mutant α …

PC Keane, PS Hanson, L Patterson, PG Blain… - Neuroscience …, 2019 - Elsevier
Parkinson's disease (PD) is characterised pathologically by degeneration of the
dopaminergic (DA) neurones of the substantia nigra pars compacta (SNpc) and the …

Pathogenesis and preclinical course of Parkinson's disease

P Foley, P Riederer - Diagnosis and treatment of parkinson's disease …, 1999 - Springer
Idiopathic parkinsonism (IP) is defined by its classic symptomology, its responsiveness to
therapies which elevate dopamine levels, and by the failure to identify a specific etiological …

The endogeneous formation of highly chlorinated tetrahydro-ß-carbolines as a possible causative mechanism in idiopathic Parkinson's disease

W Kochen, D Kohlmüller, P De Biasi… - … in Tryptophan and …, 2003 - Springer
The causative interrelationship between long-term, low level exposure to chlorinated volatile
organic solvents (VOSs) and neurodegenerative diseases (polyneuropathy …