It is a sad fact that despite being almost completely preventable through human
papillomavirus (HPV) vaccination and screening, cervical cancer remains the fourth most …

The first generation of immune checkpoint inhibitors (anti-CTLA-4 and anti-PD-1/PD-L1)
targeted natural immune homeostasis pathways, co-opted by cancers, to drive anti-tumor …

Objectives This study aimed to estimate the prevalence of genital, anal and oral HPV
infection in Brazil through systematic review and meta-analysis. Methods We searched …

Glucocorticoid‐induced tumour necrosis factor receptor‐related protein (GITR, TNFRSF18,
and CD357) is expressed at high levels in activated T cells and regulatory T cells (Tregs). In …

Autoimmune diseases decrease life expectancy and quality of life for millions of women and
men. Although treatments can slow disease progression and improve quality of life, all …

One of the mechanisms of tumor rejection in immune-modulatory treatments is antibody-
dependent cell-mediated cytotoxicity (ADCC) of regulatory T cells (Tregs) that infiltrate …

Infection with human papillomavirus (HPV) is the main cause of cervical cancer. Viral
persistence is considered the main risk factor for neoplastic progression and evidence …

Although programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) and
cytotoxic T lymphocyte antigen-4 (CTLA-4) have been successfully applied in the treatment …

As an alternative to lifelong insulin supplementation, potentiation of immune tolerance in
patients with type 1 diabetes could prevent the autoimmune destruction of pancreatic islet β …

Provided herein are antibodies, or antigen binding portions thereof, that bind to
glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in …