Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

Introduction: Mood, anxiety, and substance-use disorders are among the most prevalent
psychiatric disorders in the population. Although several pharmacological treatments are …

Abstract N, N-dimethyltryptamine (DMT) is an indole alkaloid widely found in plants and
animals. It is best known for producing brief and intense psychedelic effects when ingested …

Background: Ayahuasca, a traditional Amazonian decoction with psychoactive properties, is
made from bark of the Banisteriopsis caapi vine (containing beta-carboline alkaloids) and …

Introduction Ayahuasca is a plant-based decoction native to Amazonia, where it has a long
history of use in traditional medicine. Contemporary ritual use of ayahuasca has been …

Hallucinogens fall into several different classes, as broadly defined by pharmacological
mechanism of action, and chemical structure. These include psychedelics, entactogens …

Results: In total, 126 articles were included, encompassing 86 unique studies. Of studies
with a drug control condition (80), 49 (61.2%) used an inert placebo control, 16 (20.0%) …

In this paper, we present the development of the Altered States Database (ASDB), an open-
science project based on a systematic literature review. The ASDB contains psychometric …

Dimethyltryptamines are entheogenic serotonin-like molecules present in traditional
Amerindian medicine recently associated with cognitive gains, antidepressant effects, and …

Background: Naturalistic and placebo-controlled studies have suggested that ayahuasca, a
traditional Amazonian beverage, could be helpful in the treatment of psychopathologies like …