Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's …

MA Daulatzai - Journal of neuroscience research, 2017 - Wiley Online Library
Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin
B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse …

Vascular dysfunction in the pathogenesis of Alzheimer's disease—A review of endothelium-mediated mechanisms and ensuing vicious circles

LY Di Marco, A Venneri, E Farkas, PC Evans… - Neurobiology of …, 2015 - Elsevier
Late-onset dementia is a major health concern in the ageing population. Alzheimer's
disease (AD) accounts for the largest proportion (65–70%) of dementia cases in the older …

Heart disease as a risk factor for dementia

BN Justin, M Turek, AM Hakim - Clinical epidemiology, 2013 - Taylor & Francis
As life expectancy lengthens, dementia is becoming a significant human condition in terms
of its prevalence and cost to society worldwide. It is important in that context to understand …

Vascular risk factors, cognitve decline, and dementia

E Duron, O Hanon - Vascular health and risk management, 2008 - Taylor & Francis
Dementia is one of the most important neurological disorders in the elderly. Aging is
associated with a large increase in the prevalence and incidence of degenerative …

Role of vascular risk factors and vascular dysfunction in Alzheimer's disease

DL Dickstein, J Walsh, H Brautigam… - Mount Sinai Journal …, 2010 - Wiley Online Library
Recent findings indicate that vascular risk factors and neurovascular dysfunction play
integral roles in the pathogenesis of Alzheimer's disease. In addition to aging, the most …

Modifiable lifestyle factors in dementia: a systematic review of longitudinal observational cohort studies

LY Di Marco, A Marzo, M Muñoz-Ruiz… - Journal of …, 2014 - content.iospress.com
Background: Numerous population-based longitudinal studies suggest an association
between modifiable lifestyle factors and late-life dementia. A comprehensive description of …

The role of diet in cognitive decline

V Solfrizzi, F Panza, A Capurso - Journal of neural transmission, 2003 - Springer
Recent findings suggest a possible role of diet in age-related cognitive decline, and
cognitive impairment of both degenerative (Alzheimer's disease, AD) or vascular origin. In …

Statins: multiple neuroprotective mechanisms in neurodegenerative diseases

Q Wang, J Yan, X Chen, J Li, Y Yang, JP Weng… - Experimental …, 2011 - Elsevier
Statins have been widely used for the treatment of a variety of conditions beyond their
original role in lowering cholesterol. Since statins have relatively few side effects, they have …

Lipid metabolism in cognitive decline and dementia

F Panza, A D'Introno, AM Colacicco, C Capurso… - Brain research …, 2006 - Elsevier
This review will focus on the current knowledge on circulating serum and plasma risk factors
of cognitive decline of degenerative (Alzheimer's disease, AD) or vascular origin (vascular …

Alcohol consumption in mild cognitive impairment and dementia: harmful or neuroprotective?

F Panza, V Frisardi, D Seripa… - … journal of geriatric …, 2012 - Wiley Online Library
Objective: In several longitudinal studies, light‐to‐moderate drinking of alcoholic beverages
has been proposed as being protective against the development of age‐related changes in …