A full understanding of Parkinson's Disease etiopathogenesis and of the causes of the
preferential vulnerability of nigrostriatal dopaminergic neurons is still an unsolved puzzle. A …

Current understanding on the mechanisms of brain injury and neurodegeneration highlights
an appreciation of multicellular interactions within the neurovascular unit (NVU), which …

Parkinson's disease (PD) is a chronic neurodegenerative condition affecting more than 1%
of people over 65 years old. It is characterized by the preferential degeneration of …

Waste clearance (WC) is an essential process for brain homeostasis, which is required for
the proper and healthy functioning of all cerebrovascular and parenchymal brain cells. This …

The dopaminergic system controls several vital central nervous system functions, including
the control of movement, reward behaviors and cognition. Alterations of dopaminergic …

Parkinson's disease is a neurodegenerative disorder characterized by the death of
dopaminergic neurons and by accumulation of alpha-synuclein (aS) aggregates in the …

Aims: Oxidative stress is central to the pathogenesis of Parkinson's disease (PD), but the
mechanisms involved in the control of this stress in dopaminergic cells are not fully …

Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by elevated
concentrations of glucose in the blood. The chronic hyperglycemic state accounts for most of …

Dopamine is an important neurotransmitter that plays a critical role in motivational salience
and motor coordination. However, dysregulated dopamine metabolism can result in the …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor
dysfunction for which there is an unmet need for better treatment options. Although oxidative …