With the advent of the genetic era in Parkinson's disease (PD) research in 1997, α-synuclein
was identified as an important player in a complex neurodegenerative disease that affects> …

The blood platelet plays an important role but often remains under‐recognized in several
vascular complications and associated diseases. Surprisingly, platelet hyperactivity and …

The protein α-synuclein accumulates in the brain of patients with sporadic Parkinson's
disease (PD), and increased gene dosage causes a severe, dominantly inherited form of …

Background Brain-derived exosomes released into the blood are considered a liquid biopsy
to investigate the pathophysiological state, reflecting the aberrant heterogeneous pathways …

Background Platelets (PLT s) in stored PLT concentrates (PLC s) release PLT extracellular
vesicles (PL‐EV s) induced by senescence and activation, resembling the PLT storage …

α-Synuclein is an abundant presynaptic protein and a primary component of Lewy bodies in
Parkinson disease. Although its pathogenic role remains unclear, in healthy nerve terminals …

Gathering evidence has associated activation of microglia with the pathogenesis of
numerous neurodegenerative diseases of the central nervous system (CNS) such as …

Parkinson's disease-associated α-synuclein is an amyloidogenic protein not only expressed
in the cytoplasm of neurons, but also secreted in the extracellular space and internalized …

Many lines of evidence suggest that α‐synuclein can be secreted from cells and can
penetrate into them, although the detailed mechanism is not known. In this study, we …

Abstract α‐Synuclein (α‐syn) has been known to be a key player of the pathogenesis of
Parkinson's disease and has recently been detected in extracellular biological fluids and …