[HTML][HTML] Recent developments in synthetic approaches for macromolecular prodrugs
J Alex, C Weber, C Guerrero-Sanchez… - Progress in Polymer …, 2024 - Elsevier
In the last decades, nanoscale drug delivery systems have gained great attention partly due
to their ability to improve the bioavailability of water insoluble drugs. To this end, the general …
to their ability to improve the bioavailability of water insoluble drugs. To this end, the general …
Protective effects of tryptophan-catabolizing Lactobacillus plantarum KLDS 1.0386 against dextran sodium sulfate-induced colitis in mice
Tryptophan is an essential amino acid for the human body, whose intake is through the diet.
Several studies support the theory that microbiota-derived tryptophan metabolite played a …
Several studies support the theory that microbiota-derived tryptophan metabolite played a …
Oral delivery of layer-by-layer coated exosomes for colitis therapy
C Deng, Y Hu, M Conceição, MJA Wood… - Journal of Controlled …, 2023 - Elsevier
Mesenchymal stem cell-derived exosomes (MSC-Exos) have attracted much attention as a
potential cell-free therapy for ulcerative colitis (UC), mainly due to their anti-inflammatory …
potential cell-free therapy for ulcerative colitis (UC), mainly due to their anti-inflammatory …
Macromolecular dexamethasone prodrug ameliorates neuroinflammation and prevents bone loss associated with traumatic brain injury
Traumatic brain injury (TBI) is one of the leading causes of death and disability among
children and young adults in the United States. In this manuscript, we assessed the utility of …
children and young adults in the United States. In this manuscript, we assessed the utility of …
Discovery of a Colon-Targeted Azo Prodrug of Tofacitinib through the Establishment of Colon-Specific Delivery Systems Constructed by 5-ASA–PABA–MAC and 5 …
J Zhao, B Zhang, Q Mao, K Ping, P Zhang… - Journal of Medicinal …, 2022 - ACS Publications
To mitigate the systemic adverse effects of tofacitinib, 5-ASA–PABA–MAC and 5-ASA–PABA–
diamine colon-specific delivery systems were constructed, and tofacitinib azo prodrugs 9 …
diamine colon-specific delivery systems were constructed, and tofacitinib azo prodrugs 9 …
Thermoresponsive Polymeric Hydromorphone Prodrug Provides Sustained Local Analgesia without Apparent Adverse Effects
The extensive use of opioids for chronic pain management has contributed significantly to
the current opioid epidemic. While many alternative nonopioid analgesics are available …
the current opioid epidemic. While many alternative nonopioid analgesics are available …
Genomic and in vitro properties of the dairy Streptococcus thermophilus SMQ-301 strain against selected pathogens
Cumulative studies have suggested that probiotic bacterial strains could be an effective
alternative in inhibiting conditions caused by foodborne and vaginal pathogens. The use of …
alternative in inhibiting conditions caused by foodborne and vaginal pathogens. The use of …
Transferrin modified PEG–PLGA nanoparticles: highly effective notoginsenoside R1 formulations for the treatment of ulcerative colitis
L Zhou, Y Shang, Y Wang, X Wei - Journal of Pharmaceutical Investigation, 2024 - Springer
Purpose Ulcerative colitis (UC) is a chronic and non-specific inflammatory bowel disease
that poses a serious threat to individuals' health and lives. Notoginsenoside R1 (R1) …
that poses a serious threat to individuals' health and lives. Notoginsenoside R1 (R1) …
A Phase I, Randomized, Multi‐Dose Study to Evaluate the Enteric Selectivity and Safety of JAK Inhibitor, Lorpucitinib, in Healthy Participants
X Ma, G Borzillo, MJC Kothe, M Sanga… - Clinical …, 2024 - Wiley Online Library
Janus kinase (JAK) signaling has been implicated in human inflammatory diseases,
including psoriasis, rheumatoid arthritis, and inflammatory bowel disease. Lorpucitinib (JNJ …
including psoriasis, rheumatoid arthritis, and inflammatory bowel disease. Lorpucitinib (JNJ …