Reactive oxygen species play crucial role in biological homeostasis and pathogenesis of
human diseases including cancer. In this line, now it has become evident that ROS …

Disease relapse in cancer patients many years after clinical remission, often referred to as
cancer dormancy, is well documented but remains an incompletely understood …

To investigate miRNA function in human acute myeloid leukemia (AML) stem cells (LSC), we
generated a prognostic LSC-associated miRNA signature derived from functionally …

In a substantial fraction of prostate cancer (PCa) patients, bone metastasis appears after
years or even decades of latency. Canonical Wnt/β-catenin signaling has been proposed to …

Summary microRNAs regulate developmental cell-fate decisions, tissue homeostasis, and
oncogenesis in distinct ways relative to proteins. Here, we show that the tumor suppressor …

Significance: Reactive oxygen species (ROS), byproducts of aerobic metabolism, are
increased in many types of cancer cells. Increased endogenous ROS lead to adaptive …

Abstract Background Tyrosine kinase inhibitors (TKIs) that specifically target mutational
points in the EGFR gene have significantly reduced suffering and provided greater relief to …

Cancer heterogeneity constitutes the major source of disease progression and therapy
failure. Tumors comprise functionally diverse subpopulations, with cancer stem cells (CSCs) …

Quiescence is a state of reversible cell cycle arrest that can grant protection against many
environmental insults. In some systems, cellular quiescence is associated with a low …

Mass cytometry is a recently introduced technology that utilizes transition element isotope‐
tagged antibodies for protein detection on a single‐cell basis. By circumventing the …