Effects of pulsed, spatially fractionated, microscopic synchrotron X-ray beams on normal and tumoral brain tissue

E Bräuer-Krisch, R Serduc, EA Siegbahn… - … Research/Reviews in …, 2010 - Elsevier
Microbeam radiation therapy (MRT) uses highly collimated, quasi-parallel arrays of X-ray
microbeams of 50–600keV, produced by third generation synchrotron sources, such as the …

[HTML][HTML] Medical physics aspects of the synchrotron radiation therapies: Microbeam radiation therapy (MRT) and synchrotron stereotactic radiotherapy (SSRT)

E Bräuer-Krisch, JF Adam, E Alagoz, S Bartzsch… - Physica Medica, 2015 - Elsevier
Abstract Stereotactic Synchrotron Radiotherapy (SSRT) and Microbeam Radiation Therapy
(MRT) are both novel approaches to treat brain tumor and potentially other tumors using …

Preferential effect of synchrotron microbeam radiation therapy on intracerebral 9L gliosarcoma vascular networks

A Bouchet, B Lemasson, G Le Duc, C Maisin… - International Journal of …, 2010 - Elsevier
PURPOSE: Synchrotron microbeam radiation therapy (MRT) relies on spatial fractionation of
the incident photon beam into parallel micron-wide beams. Our aim was to analyze the …

Proton‐minibeam radiation therapy: a proof of concept

Y Prezado, GR Fois - Medical physics, 2013 - Wiley Online Library
Purpose: This Monte Carlo simulation work aims at studying a new radiotherapy approach
called proton‐minibeam radiation therapy (pMBRT). The main objective of this proof of …

Quantitative characterization of the X-ray beam at the Australian Synchrotron Imaging and Medical Beamline (IMBL)

AW Stevenson, JC Crosbie, CJ Hall… - Journal of …, 2017 - journals.iucr.org
A critical early phase for any synchrotron beamline involves detailed testing,
characterization and commissioning; this is especially true of a beamline as ambitious and …

Synchrotron microbeam radiation therapy for rat brain tumor palliation—influence of the microbeam width at constant valley dose

R Serduc, A Bouchet, E Bräuer-Krisch… - Physics in Medicine …, 2009 - iopscience.iop.org
To analyze the effects of the microbeam width (25, 50 and 75 µm) on the survival of 9L
gliosarcoma tumor-bearing rats and on toxicity in normal tissues in normal rats after …

High-precision radiosurgical dose delivery by interlaced microbeam arrays of high-flux low-energy synchrotron X-rays

R Serduc, E Bräuer-Krisch, EA Siegbahn, A Bouchet… - PLoS one, 2010 - journals.plos.org
Microbeam Radiation Therapy (MRT) is a preclinical form of radiosurgery dedicated to brain
tumor treatment. It uses micrometer-wide synchrotron-generated X-ray beams on the basis …

Increase of lifespan for glioma-bearing rats by using minibeam radiation therapy

Y Prezado, S Sarun, S Gil, P Deman… - Journal of …, 2012 - journals.iucr.org
This feasibility work assesses the therapeutic effectiveness of minibeam radiation therapy, a
new synchrotron radiotherapy technique. In this new approach the irradiation is performed …

Spatially fractionated proton minibeams

J Meyer, J Eley, TE Schmid, SE Combs… - The British journal of …, 2019 - academic.oup.com
Extraordinary normal tissue response to highly spatially fractionated X-ray beams has been
explored for over 25 years. More recently, alternative radiation sources have been …

Technical advances in x-ray microbeam radiation therapy

S Bartzsch, S Corde, JC Crosbie, L Day… - Physics in Medicine …, 2020 - iopscience.iop.org
In the last 25 years microbeam radiation therapy (MRT) has emerged as a promising
alternative to conventional radiation therapy at large, third generation synchrotrons. In MRT …