Five years on from our award-winning review on Nextgeneration sequencing and emerging
technologies, 1 a rapid pace of fundamental advances has markedly altered the landscape …

Enhancers in metazoan genomes are known to activate their target genes across both short
and long genomic distances. Recent advances in chromosome conformation capture assays …

The exact relationship between 3D chromatin interactions and enhancer function is unclear.
By probing three-dimensional enhancer interactions in developing embryos, two studies …

The early molecular events driving cancer initiation remain elusive, hampering prognostic
accuracy. A comparative analysis of 3D genomics data from all stages of colon malignant …

Two distinct lineages, pluripotent epiblast (EPI) and primitive (extra-embryonic) endoderm
(PrE), arise from common inner cell mass (ICM) progenitors in mammalian embryos. To …

Transcriptional induction coincides with the formation of various chromatin topologies.
Strong evidence supports that gene activation is accompanied by a general increase in …

Understanding the evolution of chromatin conformation among species is fundamental to
elucidate the architecture and plasticity of genomes. Nonrandom interactions of linearly …

Enhancers are critical genetic elements controlling transcription from promoters, but the
mechanisms by which they convey regulatory information across large genomic distances …

Genetic and epigenetic variations in regulatory enhancer elements increase susceptibility to
a range of pathologies. Despite recent advances, linking enhancer elements to target genes …

Dysregulation of enhancer-promoter communication in the context of the three-dimensional
(3D) nucleus is increasingly recognized as a potential driver of oncogenic programs. Here …