Navigating drug repurposing for Chagas disease: advances, challenges, and opportunities

EOJ Porta, K Kalesh, PG Steel - Frontiers in pharmacology, 2023 - frontiersin.org
Chagas disease is a vector-borne illness caused by the protozoan parasite Trypanosoma
cruzi (T. cruzi). It poses a significant public health burden, particularly in the poorest regions …

Chagas disease

AS de Sousa, D Vermeij, AN Ramos, AO Luquetti - The Lancet, 2024 - thelancet.com
Chagas disease persists as a global public health problem due to the high morbidity and
mortality burden. Despite the possibility of a cure and advances in transmission control …

Using iNaturalist presence data to produce suitability maps for Triatoma protracta, T. rubida and T. recurva in the American Southwest, Texas and northern Mexico …

J Hill, E Teal, CL Cross, Z Sanchez, MM Webber… - Scientific Reports, 2024 - nature.com
There are 11 species of triatomines in the USA, with seven reported in the American
Southwest. These species are capable of transmitting Trypanosoma cruzi, the etiological …

Fifteen Years after the Definition of Trypanosoma cruzi DTUs: What Have We Learned?

B Zingales, AM Macedo - Life, 2023 - mdpi.com
Trypanosoma cruzi, the protozoan causative of Chagas disease (ChD), exhibits striking
genetic and phenotypic intraspecific diversity, along with ecoepidemiological complexity …

The epidemiology of Chagas disease in the Americas

ZM Cucunubá, SA Gutiérrez-Romero… - The Lancet Regional …, 2024 - thelancet.com
Chagas disease is a complex parasitic zoonosis that still threatens public health across the
Americas. Initiatives to control Trypanosoma cruzi transmission via blood transfusion and …

Mechanisms behind the high mortality rate in chronic Chagas cardiomyopathy: Unmasking a three‐headed monster

LE Echeverría, AY Serrano‐García… - European Journal of …, 2024 - Wiley Online Library
Chagas disease is a neglected tropical disease caused by the parasite Trypanosoma cruzi.
Chronic Chagas cardiomyopathy (CCC), the most severe form of target organ involvement in …

The economic burden of Chagas disease: A systematic review

MV Andrade, KVMS Noronha, A de Souza… - PLOS Neglected …, 2023 - journals.plos.org
Background Chagas disease (CD) is a neglected disease affecting millions worldwide, yet
little is known about its economic burden. This systematic review is part of RAISE project, a …

Chagas disease in Europe

M Gonzalez-Sanz, C Crespillo-Andújar… - Tropical Medicine and …, 2023 - mdpi.com
Chagas disease is currently present in many non-endemic countries and remains a
neglected tropical disease globally. A review of the literature identified significant gaps and …

Chagas disease in immunocompromised patients

EH Clark, LA Messenger, JD Whitman… - Clinical Microbiology …, 2024 - Am Soc Microbiol
As Chagas disease remains prevalent in the Americas, it is important that healthcare
professionals and researchers are aware of the screening, diagnosis, monitoring, and …

Fluralaner systemic treatment of chickens results in mortality in Triatoma gerstaeckeri, vector of the agent of Chagas disease

C Durden, Y Tian, K Knape, C Klemashevich… - Parasites & …, 2023 - Springer
Background Chagas disease remains a persistent vector-borne neglected tropical disease
throughout the Americas and threatens both human and animal health. Diverse control …