An important hallmark in cancer cells is the increase in glucose uptake. GLUT1 is an
important target in cancer treatment because cancer cells upregulate GLUT1, a membrane …

Tumor cells exhibit elevated levels of glucose uptake, a phenomenon that has been
capitalized upon for the prognostic and diagnostic imaging of a wide range of cancers using …

Tumors driven by mutant KRAS are among the most aggressive and refractory to treatment.
Unfortunately, despite the efforts, targeting alterations of this GTPase, either directly or by …

Abstract Glucose transporter 1 (GLUT1), the uniporter protein encoded by the SLC2A1 gene,
is a key rate-limiting factor in the transport of glucose in cancer cells, and frequently …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal
cancers, with a five-year survival rate of around 5% to 8%. To date, very few available drugs …

Glucose, a major source of energy for all cells, is transported into cells with the help of
glucose transporters (GLUTs). These transporters are of two types, namely sodium …

The primary metabolic substrate for cells is glucose, which acts as both a source of energy
and a substrate in several processes. However, being lipophilic, the cell membrane is …

Glucose transporter (GLUT) is a group of membrane proteins which transport extracellular
glucoses into cytoplasm, amongst GLUT1 is widely up-regulated in tumor cells. However, no …

BACKGROUND Mixed lineage kinase domain‐like protein (MLKL) is a necrosome
component mediating programmed necrosis that may be an important determinant of cancer …

The outcomes of patients treated with surgery for early stage pancreatic ductal
adenocarcinoma (PDAC) are variable with median survival ranging from 6 months to more …