[HTML][HTML] Cardiac Fibrosis in heart failure: Focus on non-invasive diagnosis and emerging therapeutic strategies

S Ravassa, B López, TA Treibel, G San José… - Molecular Aspects of …, 2023 - Elsevier
Heart failure is a leading cause of mortality and hospitalization worldwide. Cardiac fibrosis,
resulting from the excessive deposition of collagen fibers, is a common feature across the …

Biomarkers in heart failure clinical trials. A review from the Biomarkers Working Group of the Heart Failure Association of the European Society of Cardiology

A Bayes‐Genis, A Aimo, P Jhund… - European Journal of …, 2022 - Wiley Online Library
The approval of new heart failure (HF) therapies has slowed over the past two decades in
part due to the high costs of conducting large randomized clinical trials that are needed to …

Myocardial fibrosis from the perspective of the extracellular matrix: mechanisms to clinical impact

IG Lunde, KB Rypdal, S Van Linthout, J Diez… - Matrix Biology, 2024 - Elsevier
Fibrosis is defined by the excessive accumulation of extracellular matrix (ECM) and
constitutes a central pathophysiological process that underlies tissue dysfunction, across …

Signaling pathways and potential therapeutic strategies in cardiac fibrosis

A Bertaud, A Joshkon, X Heim, R Bachelier… - International Journal of …, 2023 - mdpi.com
Cardiac fibrosis constitutes irreversible necrosis of the heart muscle as a consequence of
different acute (myocardial infarction) or chronic (diabetes, hypertension,…) diseases but …

Primordial non-responsiveness: a neglected obstacle to cardioprotection

G Heusch, HE Bøtker, P Ferdinandy… - European Heart …, 2023 - academic.oup.com
Schematic diagram listing the established confounders of cardioprotection and
characterizing in more detail the features of the novel confounder 'primordial non …

Formation of I2+ III2 supercomplex rescues respiratory chain defects

C Liang, A Padavannil, S Zhang, S Beh, DRL Robinson… - Cell Metabolism, 2025 - cell.com
Mitochondrial electron transport chain (ETC) complexes partition between free complexes
and quaternary assemblies known as supercomplexes (SCs). However, the physiological …

Low plasma levels of irisin predict acutely decompensated heart failure in type 2 diabetes mellitus patients with chronic heart failure

AA Berezin, AB Obradovic, IM Fushtey… - Journal of …, 2023 - mdpi.com
The aim of this study was to determine the discriminative value of irisin for acutely
decompensated heart failure (ADHF) in type 2 diabetes mellitus (T2DM) patients with …

2024 update in heart failure

A Beghini, AM Sammartino, Z Papp… - ESC Heart …, 2024 - Wiley Online Library
In the last years, major progress has occurred in heart failure (HF) management. The 2023
ESC focused update of the 2021 HF guidelines introduced new key recommendations …

Диастолическая сердечная недостаточность: 20 лет спустя. Актуальные вопросы патогенеза, диагностики и лечения сердечной недостаточности с …

ФТ Агеев, АГ Овчинников - Кардиология, 2023 - lib.ossn.ru
Аннотация Обзор посвящен анализу результатов исследований эпидемиологии,
механизмов развития, методов диагностики и лечения больных сердечной …

Diagnosis of acute myocardial infarction using a combination of circulating circular RNA cZNF292 and clinical information based on machine learning

Q Zhou, JN Boeckel, J Yao, J Zhao, Y Bai, Y Lv… - MedComm, 2023 - Wiley Online Library
Circulating circular RNAs (circRNAs) are emerging as novel biomarkers for cardiovascular
diseases (CVDs). Machine learning can provide optimal predictions on the diagnosis of …