The transcription factor FOSL1 plays an important role in cell differentiation and
tumorigenesis. Primarily, FOSL1 is crucial for the differentiation of several cell lineages …

Inflammation is an immediate response that plays a critical role in healing after fracture or
injury to bone. However, in certain clinical contexts, such as in inflammatory diseases or in …

Background: Articular cartilage lesions occur frequently but unfortunately damaged cartilage
has a very limited intrinsic repair capacity. Therefore, there is a high need to develop …

Beyond its classical role in regulation of erythropoiesis, erythropoietin (EPO) has been
shown to exert protective and regenerative actions in a variety of non‐hematopoietic tissues …

Pentraxin 3 (PTX3) is an inflammatory mediator acting as a fluid-phase pattern recognition
molecule and playing an essential role in innate immunity and matrix remodeling …

It has been well established that blood and bone share a unique, regulatory relationship
with one another, though the specifics of this relationship still remain unanswered …

Bone morphogenetic proteins (BMPs) are key signaling molecules required for normal
development of bones and other tissues. Previous studies have shown that null mutations in …

Osteoarthritis and lesions to cartilage tissue are diseases that frequently result in impaired
joint function and patient disability. The treatment of osteoarthritis, along with local bone …

Abstract Fos-related antigen-1 (FRA-1) is a member of activator protein-1 (AP-1)
transcription factor superfamily, and FRA-1 is highly expressed in colon cancer, breast …

The Fra-1/AP-1 transcription factor plays a key role in tumor epithelial cell progression;
however, its role in pathogenic lung fibrosis remains unclear. In the present study, using a …