Quasispecies theory has been instrumental in the understanding of RNA virus population
dynamics because it considered for the first time mutation as an integral part of the …

Selection of viral mutants resistant to compounds used in therapy is a major determinant of
treatment failure, a problem akin to antibiotic resistance in bacteria. In this scenario …

Lethal mutagenesis is an antiviral approach that consists in extinguishing a virus by an
excess of mutations acquired during replication in the presence of a mutagen. Here we …

Populations of RNA viruses are composed of complex and dynamic mixtures of variant
genomes that are termed mutant spectra or mutant clouds. This applies also to SARS-CoV …

A percentage of hepatitis C virus (HCV)-infected patients fail direct acting antiviral (DAA)-
based treatment regimens, often because of drug resistance-associated substitutions (RAS) …

The quasispecies dynamics of viral populations (continuous generation of variant genomes
and competition among them) has as one of its frequent consequences variations in overall …

HIV-1 transmission via sexual exposure is an inefficient process. When transmission does
occur, newly infected individuals are colonized by the descendants of either a single virion …

Background and Purpose There is a need for effective anti‐COVID‐19 treatments, mainly for
individuals at risk of severe disease such as the elderly and the immunosuppressed. Drug …

The changes occurring in viral quasispecies populations during infection have been
monitored using diversity indices, nucleotide diversity, and several other indices to …

Conclusions: Baseline NS5A-RAS can compromise the efficacy of double-DAA
pangenotypic regimens for HCV genotype 3, and enhanced viral fitness can accelerate …