The onset of cardiomyopathy is a common feature in sepsis, with relevant effects on its
pathophysiology and clinical care. Septic cardiomyopathy is characterized by reduced left …

Sepsis is a serious complication after infection, whose further development may lead to
multiple organ dysfunction syndrome and so on. It is an important cause of death in critically …

Background Septic cardiomyopathy worsens the prognosis of critically ill patients. Clinical
data suggest that interleukin‐1β (IL‐1β), activated by the NLRP3 inflammasome …

Objectives: The mechanism (s) for septic cardiomyopathy in humans is not known. To
address this, we measured messenger RNA alterations in hearts from patients who died …

Animal experiments are widely used in preclinical medical research with the goal of disease
modeling and exploration of novel therapeutic approaches. In the context of sepsis and …

Septic cardiomyopathy (SCM) is a common complication of sepsis contributing to high
mortality rates. Its pathophysiology involves complex factors, including inflammatory …

Cardiac dysfunction may complicate the course of severe sepsis and septic shock with
significant implications for patient's survival. The basic pathophysiologic mechanisms …

Calpains are a family of cysteine proteases, implicated in a wide range of cellular calcium‑
regulated functions. Evidence from previous studies using an inhibitor of calpain indicates …

Calcium dysregulation and mitochondrial dysfunction are key elements in the development
of sepsis-induced cardiac dysfunction. Evidences have suggested that inhibition of Wnt/β …

Sepsis is a life-threatening condition that occurs when the body responds to an infection
damaging its own tissues. Sepsis survivors sometimes suffer from immunosuppression …