The β Subunit of Voltage-Gated Ca2+ Channels

Z Buraei, J Yang - Physiological reviews, 2010 - journals.physiology.org
Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle
contraction, neuronal communication, hormone release, cell division, and gene …

Supramolecular assemblies and localized regulation of voltage-gated ion channels

S Dai, DD Hall, JW Hell - Physiological reviews, 2009 - journals.physiology.org
This review addresses the localized regulation of voltage-gated ion channels by
phosphorylation. Comprehensive data on channel regulation by associated protein kinases …

Structure of a complex between a voltage-gated calcium channel β-subunit and an α-subunit domain

F Van Petegem, KA Clark, FC Chatelain, DL Minor Jr - Nature, 2004 - nature.com
Voltage-gated calcium channels (CaVs) govern muscle contraction, hormone and
neurotransmitter release, neuronal migration, activation of calcium-dependent signalling …

Coding and noncoding variation of the human calcium-channel β4-subunit gene CACNB4 in patients with idiopathic generalized epilepsy and episodic ataxia

A Escayg, M De Waard, DD Lee, D Bichet… - The American Journal of …, 2000 - cell.com
Inactivation of the β 4 subunit of the calcium channel in the mouse neurological mutant
lethargic results in a complex neurological disorder that includes absence epilepsy and …

The I-II loop of the Ca2+ channel α1 subunit contains an endoplasmic reticulum retention signal antagonized by the β subunit

D Bichet, V Cornet, S Geib, E Carlier, S Volsen, T Hoshi… - Neuron, 2000 - cell.com
The auxiliary β subunit is essential for functional expression of high voltage-activated Ca 2+
channels. This effect is partly mediated by a facilitation of the intracellular trafficking of α 1 …

β subunits of voltage-gated calcium channels

AC Dolphin - Journal of bioenergetics and biomembranes, 2003 - Springer
Calcium channel β subunits have marked effects on the trafficking and on several of the
biophysical properties of all high voltage activated calcium channels. In this article I shall …

[HTML][HTML] Structural analysis of the voltage-dependent calcium channel β subunit functional core and its complex with the α1 interaction domain

Y Opatowsky, CC Chen, KP Campbell, JA Hirsch - Neuron, 2004 - cell.com
Voltage-dependent calcium channels (VDCC) are multiprotein assemblies that regulate the
entry of extracellular calcium into electrically excitable cells and serve as signal transduction …

[HTML][HTML] Structure and function of the β subunit of voltage-gated Ca2+ channels

Z Buraei, J Yang - Biochimica Et Biophysica Acta (BBA)-Biomembranes, 2013 - Elsevier
The voltage-gated Ca2+ channel β subunit (Cavβ) is a cytosolic auxiliary subunit that plays
an essential role in regulating the surface expression and gating properties of high-voltage …

Cannabinoid CB1 receptors control conditioned drug seeking

TJ De Vries, ANM Schoffelmeer - Trends in pharmacological sciences, 2005 - cell.com
Recent developments have implicated cannabinoid CB 1 receptors as a novel target for a
new class of therapeutic agents used to treat drug addiction. CB 1 receptors are expressed …

Critical Role of cAMP-Dependent Protein Kinase Anchoring to the L-Type Calcium Channel Cav1.2 via A-Kinase Anchor Protein 150 in Neurons

DD Hall, MA Davare, M Shi, ML Allen… - Biochemistry, 2007 - ACS Publications
The cAMP-dependent protein kinase (PKA) regulates a wide array of cellular functions. In
brain and heart PKA increases the activity of the L-type Ca2+ channel Cav1. 2 in response …