Even when split into several chromosomes, DNA molecules that make up our genome are
too long to fit into the cell nuclei unless massively folded. Such folding must accommodate …

Large-scale cancer genome sequencing studies have revealed that chromatin regulators
are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations …

Nucleosomes represent elementary building units of eukaryotic chromosomes and consist of
DNA wrapped around a histone octamer flanked by linker DNA segments. Nucleosomes are …

Hexasomes are non-canonical nucleosomes that package DNA with six instead of eight
histones. First discovered 40 years ago as a consequence of transcription, two near-atomic …

Aging probably is the most complexed process in biology. It is manifested by a variety of
hallmarks. These hallmarks weave a network of aging; however, each hallmark is not …

The intersection of metabolic processes and epigenetic regulation during embryogenesis is
crucial yet not fully understood. Through a candidate RNAi screen in Caenorhabditis …

Chromatin remodelling complexes (CRC) are ATP-dependent molecular machines
important for the dynamic organization of nucleosomes along eukaryotic DNA. CRCs …

Chromatin remodelers are molecular motors that act on nucleosomes: they move them
along DNA or (dis-) assemble them. Despite the fact that they perform essential regulatory …

Histone post-translational modifications and variants play crucial roles in the adaptability of
chromatin structure, facilitating rapid responses necessary for biological processes such as …

H2A. Z is a conserved histone variant that is localized to specific genomic regions where it
plays important roles in transcription, DNA repair, and replication. Central to the …