Cisplatin has dramatically improved the survival rate of cancer patients, but it has also
increased the prevalence of hearing and neurological deficits in this population. Cisplatin …

Cisplatin is a platinum-based chemotherapeutic that has long since been effective against a
variety of solid-cancers, substantially improving the five-year survival rates for cancer …

Introduction Cisplatin is a very effective chemotherapeutic agent against a variety of solid
tumors. Unfortunately, cisplatin causes permanent sensorineural hearing loss in at least two …

Objective: This review will summarise the current state of development of pharmaceutical
interventions (prevention or treatment) for medication-induced ototoxicity. Design: Currently …

Tinnitus is defined as the perception of sound in the absence of external acoustic stimuli.
Frequent comorbidities or associated factors are depression, anxiety, concentration …

Objectives Cisplatin, one of the most effective and widely used chemotherapeutic agents in
the treatment of head and neck malignancies, has severe dose-limiting side effects including …

Introduction: Sensorineural hearing loss (HL) is becoming a global phenomenon at an
alarming rate. Nearly 600 million people have been estimated to have significant HL in at …

Background: Cisplatin-induced ototoxicity is related to oxidative stress. Astaxanthin is one of
the most powerful antioxidants in nature. Aims/objectives: To investigate the protective effect …

The chemotherapeutic drug cisplatin causes a number of dose-dependent side effects,
including cachexia and testicular damage. Patients receiving a high cumulative dose of …

OBJECTIVE The purpose of this study was to examine the anti-ototoxic impact of Ginkgo
biloba extract and lycopene on the model of cisplatin-induced ototoxicity in rats. MATERIALS …