Engineering considerations of iPSC-based personalized medicine
Personalized medicine aims to provide tailored medical treatment that considers the clinical,
genetic, and environmental characteristics of patients. iPSCs have attracted considerable …
genetic, and environmental characteristics of patients. iPSCs have attracted considerable …
Induced pluripotency in the context of stem cell expansion bioprocess development, optimization, and manufacturing: a roadmap to the clinic
The translation of laboratory-scale bioprocess protocols and technologies to industrial
scales and the application of human induced pluripotent stem cell (hiPSC) derivatives in …
scales and the application of human induced pluripotent stem cell (hiPSC) derivatives in …
Upscaling human mesenchymal stromal cell production in a novel vertical-wheel bioreactor enhances extracellular vesicle secretion and cargo profile
Human mesenchymal stromal cells (hMSCs) are mechanically sensitive undergoing
phenotypic alterations when subjected to shear stress, cell aggregation, and substrate …
phenotypic alterations when subjected to shear stress, cell aggregation, and substrate …
Engineering 3D micro-compartments for highly efficient and scale-independent expansion of human pluripotent stem cells in bioreactors
PJR Cohen, E Luquet, J Pletenka, A Leonard, E Warter… - Biomaterials, 2023 - Elsevier
Human pluripotent stem cells (hPSCs) have emerged as the most promising cellular source
for cell therapies. To overcome the scale-up limitations of classical 2D culture systems …
for cell therapies. To overcome the scale-up limitations of classical 2D culture systems …
Overcoming bioprocess bottlenecks in the large-scale expansion of high-quality hiPSC aggregates in vertical-wheel stirred suspension bioreactors
BS Borys, T Dang, T So, L Rohani, T Revay… - Stem Cell Research & …, 2021 - Springer
Background Human induced pluripotent stem cells (hiPSCs) hold enormous promise in
accelerating breakthroughs in understanding human development, drug screening, disease …
accelerating breakthroughs in understanding human development, drug screening, disease …
Suspension culture improves iPSC expansion and pluripotency phenotype
Background Induced pluripotent stem cells (iPSCs) offer potential to revolutionize
regenerative medicine as a renewable source for islets, dopaminergic neurons, retinal cells …
regenerative medicine as a renewable source for islets, dopaminergic neurons, retinal cells …
Strong elastic protein nanosheets enable the culture and differentiation of induced pluripotent stem cells on microdroplets
E Mojares, C Nadal, D Hayler, H Kanso… - Advanced …, 2024 - Wiley Online Library
Advances in stem cell technologies, revolutionizing regenerative therapies and advanced in
vitro testing, require novel cell manufacturing pipelines able to cope with scale up and …
vitro testing, require novel cell manufacturing pipelines able to cope with scale up and …
Transformative materials to create 3D functional human tissue models in vitro in a reproducible manner
Recreating human tissues and organs in the petri dish to establish models as tools in
biomedical sciences has gained momentum. These models can provide insight into …
biomedical sciences has gained momentum. These models can provide insight into …
A scalable system for generation of mesenchymal stem cells derived from induced pluripotent cells employing bioreactors and degradable microcarriers
Human mesenchymal stem cells (hMSCs) are effective in treating disorders resulting from
an inflammatory or heightened immune response. The hMSCs derived from induced …
an inflammatory or heightened immune response. The hMSCs derived from induced …
Profiling biomanufactured extracellular vesicles of human forebrain spheroids in a Vertical‐Wheel Bioreactor
Extracellular vesicles (EVs) secreted by human brain cells have great potential as cell‐free
therapies in various diseases, including stroke. However, because of the significant amount …
therapies in various diseases, including stroke. However, because of the significant amount …