In the last two decades, multi (MDR), extensively (XDR), extremely (XXDR) and total (TDR)
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …

Tuberculosis (TB) remains one of the greatest threats to human health. The causative
bacterium, Mycobacterium tuberculosis (Mtb), is acquired by the respiratory route. It is …

Tuberculosis (TB) is a leading cause worldwide of human mortality attributable to a single
infectious agent. Recent studies targeting candidate genes and “case-control” association …

Approximately one third of the world's population is infected with Mycobacterium
tuberculosis, the causative agent of tuberculosis. This bacterium has an unusual lipid-rich …

Tuberculosis is still a major health problem in the world. Initial interactions between
Mycobacterium tuberculosis and the host mark the pathway of infection and the subsequent …

We establish a murine lung-on-chip infection model and use time-lapse imaging to reveal
the dynamics of host-Mycobacterium tuberculosis interactions at an air-liquid interface with a …

Life originated in anoxia, but many organisms came to depend upon oxygen for survival,
independently evolving diverse respiratory systems for acquiring oxygen from the …

Tuberculosis (TB) is an international public health priority and kills almost two million people
annually. TB is out of control in Africa due to increasing poverty and HIV coinfection, and …

Pulmonary surfactant (PS) has been extensively studied because of its primary role in
mammalian breathing. The deposition of this surface-active material at the alveolar air-water …

Lungs are directly exposed to the air, have enormous surface area, and enable gas
exchange in air-breathing animals. They are constantly 'attacked'by microbes from both …