Insight into TLR4-mediated immunomodulation in normal pregnancy and related disorders

P Firmal, VK Shah, S Chattopadhyay - Frontiers in immunology, 2020 - frontiersin.org
Unlike organ transplants where an immunosuppressive environment is required, a
successful pregnancy involves an extremely robust, dynamic, and responsive maternal …

Training the fetal immune system through maternal inflammation—a layered hygiene hypothesis

AC Apostol, KDC Jensen, AE Beaudin - Frontiers in immunology, 2020 - frontiersin.org
Over the last century, the alarming surge in allergy and autoimmune disease has led to the
hypothesis that decreasing exposure to microbes, which has accompanied industrialization …

Understanding the immune system in fetal protection and maternal infections during pregnancy

T Hussain, G Murtaza, DH Kalhoro… - Journal of …, 2022 - Wiley Online Library
The fetal‐maternal immune system determines the fate of pregnancy. The trophoblast cells
not only give an active response against external stimuli but are also involved in secreting …

Inflammasome activation and IL-1 signaling during placental malaria induce poor pregnancy outcomes

AS Reis, R Barboza, O Murillo, A Barateiro… - Science …, 2020 - science.org
Placental malaria (PM) is associated with severe inflammation leading to abortion, preterm
delivery, and intrauterine growth restriction. Innate immunity responses play critical roles, but …

[HTML][HTML] Placental inflammatory injury induced by chlorinated polyfluorinated ether sulfonate (F-53B) through NLRP3 inflammasome activation

C Chu, H Ran, Y Zhou, K Zhao, YT Zhang… - Ecotoxicology and …, 2024 - Elsevier
Chlorinated polyfluorinated ether sulfonate, commercially known as F-53B, has been
associated with adverse birth outcomes. However, the reproductive toxicology of F-53B on …

Contribution of murine models to the study of malaria during pregnancy

A Barateiro, MLM Pereira, S Epiphanio… - Frontiers in …, 2019 - frontiersin.org
Annually, many pregnancies occur in areas of Plasmodium spp. transmission, particularly in
underdeveloped countries with widespread poverty. Estimations have suggested that …

TLR4-endothelin axis controls syncytiotrophoblast motility and confers fetal protection in placental malaria

Y Pandya, A Marta, A Barateiro, CL Bandeira… - Infection and …, 2021 - Am Soc Microbiol
Pregnancy-associated malaria is often associated with adverse pregnancy outcomes.
Placental circulatory impairments are an intriguing and unsolved component of malaria …

Potential pharmacologic interventions targeting TLR signaling in placental malaria

FM Kobia, K Maiti, MM Obimbo, R Smith, J Gitaka - Trends in parasitology, 2022 - cell.com
Complications from placental malaria cause poor pregnancy outcomes, including low
birthweight, preterm delivery, and stillbirths. Many of these complications are driven by …

SEPSIS project: a protocol for studying biomarkers of neonatal sepsis and immune responses of infants in a malaria-endemic region

N Fievet, S Ezinmegnon, G Agbota, D Sossou… - BMJ open, 2020 - bmjopen.bmj.com
Introduction Neonatal sepsis outreaches all causes of neonatal mortality worldwide and
remains a major societal burden in low and middle income countries. In addition to limited …

Homeostasis Maintenance in Plasmodium-Infected Placentas: Is There a Role for Placental Autophagy During Malaria in Pregnancy?

A Barateiro, ARC Junior, S Epiphanio… - Frontiers in …, 2022 - frontiersin.org
Malaria represents a significant public health burden to populations living in developing
countries. The disease takes a relevant toll on pregnant women, who are more prone to …