Psoriasis: pathological mechanisms, current pharmacological therapies, and emerging drug delivery systems

VK Rapalli, T Waghule, S Gorantla, SK Dubey… - Drug Discovery …, 2020 - Elsevier
Highlights•Psoriasis pathogenesis involved cytokines, microbial peptides, genetic
disposition.•Psoriasis is autoimmune disorder that affects approximately 125 million …

Phosphodiesterase-4 inhibition in psoriasis

M Milakovic, MJ Gooderham - Psoriasis: Targets and Therapy, 2021 - Taylor & Francis
Psoriasis is a chronic immune-mediated inflammatory disorder. Phosphodiesterase-4 (PDE-
4) is an enzyme that mediates inflammatory responses and plays a role in psoriasis …

Itch: an under‐recognized problem in psoriasis

B Elewski, AF Alexis, M Lebwohl… - Journal of the …, 2019 - Wiley Online Library
Psoriasis has historically been considered a nonpruritic dermatosis, in contrast with atopic
dermatitis. Thus, itch has often been underappreciated and overlooked in psoriasis …

New and emerging oral/topical small-molecule treatments for psoriasis

E Carmona-Rocha, L Rusiñol, L Puig - Pharmaceutics, 2024 - mdpi.com
The introduction of biologic therapies has led to dramatic improvements in the management
of moderate-to-severe psoriasis. Even though the efficacy and safety of the newer biologic …

Personalized medicine—concepts, technologies, and applications in inflammatory skin diseases

T Litman - Apmis, 2019 - Wiley Online Library
The current state, tools, and applications of personalized medicine with special emphasis on
inflammatory skin diseases like psoriasis and atopic dermatitis are discussed. Inflammatory …

[HTML][HTML] New and emerging topical therapies for psoriasis and atopic dermatitis

CE Psomadakis, G Han - The Journal of Clinical and Aesthetic …, 2019 - ncbi.nlm.nih.gov
Psoriasis and atopic dermatitis represent two of the most common skin conditions seen by
both primary care and specialist dermatology. The prevalence of psoriasis in North America …

Topical Management of Pediatric Psoriasis: A Review of New Developments and Existing Therapies

E Lie, M Choi, SP Wang, LF Eichenfield - Pediatric Drugs, 2024 - Springer
Psoriasis is a chronic immune-mediated disorder that commonly affects adults and children.
In recent years, pediatric psoriasis has increased in prevalence and the disease is often …

Phosphodiesterase-4 Inhibition in the Management of Psoriasis

EL Crowley, MJ Gooderham - Pharmaceutics, 2023 - mdpi.com
Psoriasis is a common chronic immune-mediated disease with many comorbidities and
impacts on quality of life. Among the treatments for psoriasis, phosphodiesterase-4 (PDE4) …

Plaque-type psoriasis inhibitors

SS Shobeiri, M Khorrami, M Sankian - International Immunopharmacology, 2021 - Elsevier
Psoriasis is a common inflammatory skin disorder, which is mediated by the immune system
and affects 1–4% of the world's population. Psoriasis is caused by a complex interaction …

Small molecules under development for psoriasis: on the road to the individualized therapies

CD Claudia, VH María-Elena, VE Josué… - Archives of …, 2020 - Springer
Psoriasis is an incurable cutaneous illness characterized by the presence of well-delimited
reddish plaques and silvery-white dry scales. So far, there is a limited understanding of its …