Human and animal studies suggest an intriguing link between mitochondrial diseases and
depression. Although depression has historically been linked to alterations in …

In mood disorders, there is growing evidence for glutamatergic abnormalities derived from
peripheral measures of glutamatergic metabolites in patients, postmortem studies on …

Context Accumulating evidence suggests that mitochondrial dysfunction and oxidative stress
contribute to the pathogenesis of bipolar disorder and schizophrenia. It remains unclear …

Bipolar disorder (BPD) and schizophrenia (SZ) are severe psychiatric illnesses with a
combined prevalence of 4%. A disturbance of energy metabolism is frequently observed in …

Current literature on the effects of chronic stress in general health converges to the concept
of allostatic load (AL). AL is the bodily 'wear and tear'that emerges with sustained allostatic …

Athletes, body builders, and military personnel use dietary creatine as an ergogenic aid to
boost physical performance in sports involving short bursts of high-intensity muscle activity …

Postmortem, genetic, brain imaging, and peripheral cell studies all support decreased
mitochondrial activity as a factor in the manifestation of Bipolar Disorder (BD). Because …

Gigante AD, Bond DJ, Lafer B, Lam RW, Young LT, Yatham LN. Brain glutamate levels
measured by magnetic resonance spectroscopy in patients with bipolar disorder: a meta …

Background Bipolar disorder phenomenologically is a biphasic disorder of energy
availability; increased in mania and decreased in depression. In consort, there is …

This meta-analysis evaluates alterations of neurometabolites in schizophrenia and bipolar
disorder. PubMed was searched to find controlled studies evaluating N-acetylaspartate …