Innovations in genomic antimicrobial resistance surveillance

NE Wheeler, V Price, E Cunningham-Oakes… - The Lancet …, 2023 - thelancet.com
Whole-genome sequencing of antimicrobial-resistant pathogens is increasingly being used
for antimicrobial resistance (AMR) surveillance, particularly in high-income countries …

Clinical Diagnostics of Bacterial Infections and Their Resistance to Antibiotics—Current State and Whole Genome Sequencing Implementation Perspectives

E Avershina, A Khezri, R Ahmad - Antibiotics, 2023 - mdpi.com
Antimicrobial resistance (AMR), defined as the ability of microorganisms to withstand
antimicrobial treatment, is responsible for millions of deaths annually. The rapid spread of …

A comprehensive review on genomics, systems biology and structural biology approaches for combating antimicrobial resistance in ESKAPE pathogens …

P Priyamvada, R Debroy, A Anbarasu… - World Journal of …, 2022 - Springer
In recent decades, antimicrobial resistance has been augmented as a global concern to
public health owing to the global spread of multidrug-resistant strains from different ESKAPE …

Hybrid Assembly Provides Improved Resolution of Plasmids, Antimicrobial Resistance Genes, and Virulence Factors in Escherichia coli and Klebsiella pneumoniae …

A Khezri, E Avershina, R Ahmad - Microorganisms, 2021 - mdpi.com
Emerging new sequencing technologies have provided researchers with a unique
opportunity to study factors related to microbial pathogenicity, such as antimicrobial …

The population genomics of increased virulence and antibiotic resistance in human commensal Escherichia coli over 30 years in France

J Marin, O Clermont, G Royer… - Applied and …, 2022 - Am Soc Microbiol
Escherichia coli is a commensal species of the lower intestine but is also a major pathogen
causing intestinal and extraintestinal infections that is increasingly prevalent and resistant to …

Highly sensitive quantitative phase microscopy and deep learning aided with whole genome sequencing for rapid detection of infection and antimicrobial resistance

A Ahmad, R Hettiarachchi, A Khezri… - Frontiers in …, 2023 - frontiersin.org
Current state-of-the-art infection and antimicrobial resistance (AMR) diagnostics are based
on culture-based methods with a detection time of 48–96 h. Therefore, it is essential to …

Ultrafast and cost-effective pathogen identification and resistance gene detection in a clinical setting using nanopore flongle sequencing

E Avershina, SA Frye, J Ali, AM Taxt… - Frontiers in …, 2022 - frontiersin.org
Rapid bacterial identification and antimicrobial resistance gene (ARG) detection are crucial
for fast optimization of antibiotic treatment, especially for septic patients where each hour of …

Molecular Epidemiology and Colistin-Resistant Mechanism of mcr-Positive and mcr-Negative Escherichia coli Isolated From Animal in Sichuan Province, China

F Li, P Cheng, X Li, R Liu, H Liu, X Zhang - Frontiers in Microbiology, 2022 - frontiersin.org
Colistin is the last line of defense for the treatment of multidrug-resistant gram-negative
bacterial infections. However, colistin resistance is gradually increasing worldwide, with …

Effect of cattle farm exposure on oropharyngeal and gut microbial communities and antibiotic resistance genes in workers

D Ding, J Zhu, Y Gao, F Yang, Y Ma, X Cheng… - Science of the Total …, 2022 - Elsevier
Livestock farms are recognized as the main sources of antibiotic resistance genes (ARGs)
and antibiotic-resistant bacteria (ARB) with potential implications for human health. In this …

Profiling the Virulence and Antibiotic Resistance Genes of Cronobacter sakazakii Strains Isolated From Powdered and Dairy Formulas by Whole-Genome …

J Parra-Flores, O Holý, F Riffo, S Lepuschitz… - Frontiers in …, 2021 - frontiersin.org
Cronobacter sakazakii is an enteropathogen that causes neonatal meningitis, septicemia,
and necrotizing enterocolitis in preterm infants and newborns with a mortality rate of 15 to …