Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are uniquely
required to balance the formation of new blood vessels with the maintenance and …

Collective cell migration has a key role during morphogenesis and during wound healing
and tissue renewal in the adult, and it is involved in cancer spreading. In addition to …

Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …

Integrins are vital surface adhesion receptors that mediate interactions between the
extracellular matrix (ECM) and cells and are essential for cell migration and the …

The function of vascular endothelial growth factor (VEGF) in cancer is not limited to
angiogenesis and vascular permeability. VEGF-mediated signalling occurs in tumour cells …

The extracellular matrix (ECM) constitutes the main acellular microenvironment of cells in
almost all tissues and organs. The ECM not only provides mechanical support, but also …

The integrin family of cell adhesion receptors regulates a diverse array of cellular functions
crucial to the initiation, progression and metastasis of solid tumours. The importance of …

Integrins are transmembrane receptors that have been implicated in the biology of various
human physiological and pathological processes. These molecules facilitate cell …

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen in vitro and
an angiogenic inducer in a variety of in vivo models. Hypoxia has been shown to be a major …

Endothelial cell migration is essential to angiogenesis. This motile process is directionally
regulated by chemotactic, haptotactic, and mechanotactic stimuli and further involves …