Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical potential

L Gao, Y Zhang, K Sterling, W Song - Translational neurodegeneration, 2022 - Springer
Synaptic abnormalities are a cardinal feature of Alzheimer's disease (AD) that are known to
arise as the disease progresses. A growing body of evidence suggests that pathological …

Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders

M Notaras, M van den Buuse - Molecular psychiatry, 2020 - nature.com
Brain-derived neurotrophic factor (BDNF) is widely accepted for its involvement in resilience
and antidepressant drug action, is a common genetic locus of risk for mental illnesses, and …

The role of BDNF on neural plasticity in depression

T Yang, Z Nie, H Shu, Y Kuang, X Chen… - Frontiers in cellular …, 2020 - frontiersin.org
Using behavioral, pharmacological, and molecular methods, lots of studies reveal that
depression is closely related to the abnormal neural plasticity processes occurring in the …

BDNF and hippocampal synaptic plasticity

G Leal, CR Bramham, CB Duarte - Vitamins and hormones, 2017 - Elsevier
Brain-derived neurotrophic factor (BDNF) belongs to a family of small secreted proteins that
also include nerve growth factor, neurotrophin 3, and neurotrophin 4. BDNF stands out …

Brain-derived neurotrophic factor in mood disorders and antidepressant treatments

E Castrén, M Kojima - Neurobiology of disease, 2017 - Elsevier
Levels of brain-derived neurotrophic factor (BDNF) are reduced in the brain and serum of
depressed patients and at least the reduction in serum levels is reversible upon successful …

Brain-derived neurotropic factor in neurodegenerative disorders

AM Ibrahim, L Chauhan, A Bhardwaj, A Sharma… - Biomedicines, 2022 - mdpi.com
Globally, neurodegenerative diseases cause a significant degree of disability and distress.
Brain-derived neurotrophic factor (BDNF), primarily found in the brain, has a substantial role …

Neuronal plasticity and neurotrophic factors in drug responses

E Castrén, H Antila - Molecular psychiatry, 2017 - nature.com
Neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF) and other
members of the neurotrophin family, are central mediators of the activity-dependent plasticity …

BDNF effects on dendritic spine morphology and hippocampal function

O von Bohlen und Halbach… - Cell and tissue …, 2018 - Springer
Neurotrophins, including brain-derived neurotrophic factor (BDNF), are expressed in the
hippocampus, as well as their precursors, the pro-neurotrophins. The neurotrophins signal …

Modulation of serum brain-derived neurotrophic factor by a single dose of ayahuasca: observation from a randomized controlled trial

RN Almeida, ACM Galvão, FS da Silva… - Frontiers in …, 2019 - frontiersin.org
Serotonergic psychedelics are emerging as potential antidepressant therapeutic tools, as
suggested in a recent randomized controlled trial with ayahuasca for treatment-resistant …

Long‐term plasticity in the hippocampus: maintaining within and 'tagging'between synapses

MZ Bin Ibrahim, A Benoy, S Sajikumar - The FEBS journal, 2022 - Wiley Online Library
Synapses between neurons are malleable biochemical structures, strengthening and
diminishing over time dependent on the type of information they receive. This phenomenon …