Pharmacokinetics (PK) is the study of the absorption, distribution, metabolism, and excretion
(ADME) processes of a drug. Understanding PK properties is essential for drug development …

Chronic diseases are a significant healthcare problem. Partial or complete non-
responsiveness to chronic therapies is a significant obstacle to maintaining the long-term …

The efficacy and safety of drugs are widely known to be determined by their interactions with
multiple molecules of pharmacological importance, and it is therefore essential to …

Widespread drug resistance has become the key issue in global healthcare. Extensive
efforts have been made to reveal not only diverse diseases experiencing drug resistance …

Drug-metabolizing enzymes (DMEs) are critical determinant of drug safety and efficacy, and
the interactome of DMEs has attracted extensive attention. There are 3 major interaction …

Abstract Androgen receptor-(AR-) indifference is a mechanism of resistance to hormonal
therapy in prostate cancer (PC). Here we demonstrate that ONECUT2 (OC2) activates …

Nonalcoholic steatohepatitis (NASH) is a progressive liver disease and has become a
leading indication for liver transplantation in the United States. The development of effective …

UDP-glucuronosyltransferases (UGTs) are the primary phase II enzymes catalyzing the
conjugation of glucuronic acid to the xenobiotics with polar groups for facilitating their …

Unraveling the intricacies of β-glucuronidase inhibition is pivotal for developing effective
strategies in applications specific to gastrointestinal health and drug metabolism. Our study …

The organic anion transporters OAT1 (SLC22A6) and OAT3 (SLC22A8) have similar
substrate specificity for drugs, but it is far from clear whether this holds for endogenous …