Hepatic stellate cells: central modulators of hepatic carcinogenesis

AI Thompson, KP Conroy, NC Henderson - BMC gastroenterology, 2015 - Springer
Hepatocellular carcinoma (HCC) represents the second most common cause of cancer-
related death worldwide, and is increasing in incidence. Currently, our therapeutic repertoire …

[HTML][HTML] Treating Cancer through Modulating Exosomal Protein Loading and Function: The Prospects of Natural Products and Traditional Chinese Medicine

L Meng, C Zhang, P Yu - Pharmacological Research, 2024 - Elsevier
Exosomes, small yet vital extracellular vesicles, play an integral role in intercellular
communication. They transport critical components, such as proteins, lipid bilayers, DNA …

SERPINA5 promotes tumour cell proliferation by modulating the PI3K/AKT/mTOR signalling pathway in gastric cancer

M Fan, X Xiong, L Han, L Zhang, S Gao… - Journal of Cellular …, 2022 - Wiley Online Library
SERPINA5 belongs to the serine protease inhibitor superfamily and has been reported to be
lowly expressed in a variety of malignancies. However, few report of SERPINA5 in gastric …

Integrated GlycoProteome Analyzer (I-GPA) for automated identification and quantitation of site-specific N-glycosylation

GW Park, JY Kim, H Hwang, JY Lee, YH Ahn, HK Lee… - Scientific reports, 2016 - nature.com
Human glycoproteins exhibit enormous heterogeneity at each N-glycosite, but few studies
have attempted to globally characterize the site-specific structural features. We have …

[HTML][HTML] Inactivation of interleukin-30 in colon cancer stem cells via CRISPR/Cas9 genome editing inhibits their oncogenicity and improves host survival

L D'Antonio, C Fieni, SL Ciummo, S Vespa… - … for Immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background Progression of colorectal cancer (CRC), a leading cause of cancer-related
death worldwide, is driven by colorectal cancer stem cells (CR-CSCs), which are regulated …

[HTML][HTML] MicroRNA-135b, a HSF1 target, promotes tumor invasion and metastasis by regulating RECK and EVI5 in hepatocellular carcinoma

Y Li, D Xu, C Bao, Y Zhang, D Chen, F Zhao, J Ding… - Oncotarget, 2015 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) often localize to chromosomal fragile sites and are associated with
cancer. In this study, we screened for the aberrant and functional miRNAs in the regions of …

Effect of p53 and its N‐terminally truncated isoform, Δ40p53, on breast cancer migration and invasion

X Zhang, K Groen, BC Morten… - Molecular …, 2022 - Wiley Online Library
Breast cancer is the most diagnosed malignancy in women, with over half a million women
dying from this disease each year. In our previous studies,∆ 40p53, an N‐terminally …

Family wide molecular adaptations to underground life in African mole-rats revealed by phylogenomic analysis

KTJ Davies, NC Bennett… - Molecular Biology …, 2015 - academic.oup.com
During their evolutionary radiation, mammals have colonized diverse habitats. Arguably the
subterranean niche is the most inhospitable of these, characterized by reduced oxygen …

Comprehensive analysis of mRNAs and miRNAs in the ovarian follicles of uniparous and multiple goats at estrus phase

X Zou, T Lu, Z Zhao, G Liu, Z Lian, Y Guo, B Sun, D Liu… - BMC genomics, 2020 - Springer
Background Fertility is an important economic trait in the production of meat goat, and
follicular development plays an important role in fertility. Although many mRNAs and …

Fibronectin promotes cell growth and migration in human renal cell carcinoma cells

YC Ou, JR Li, JD Wang, CY Chang, CC Wu… - International Journal of …, 2019 - mdpi.com
The prognostic and therapeutic values of fibronectin have been reported in patients with
renal cell carcinoma (RCC). However, the underlying mechanisms of malignancy in RCC …