[HTML][HTML] Mechanisms of pathogenesis and environmental moderators in preclinical models of compulsive-like behaviours
Obsessive-compulsive and related disorders (OCRD) is an emergent class of psychiatric
illnesses that contributes substantially to the global mental health disease burden. In …
illnesses that contributes substantially to the global mental health disease burden. In …
Invasive and non-invasive neurostimulation for OCD
IO Bergfeld, E Dijkstra, I Graat, P de Koning… - The Neurobiology and …, 2021 - Springer
It becomes increasingly clear that (non-) invasive neurostimulation is an effective treatment
for obsessive-compulsive disorder (OCD). In this chapter we review the available evidence …
for obsessive-compulsive disorder (OCD). In this chapter we review the available evidence …
[HTML][HTML] Pathway-specific alterations in striatal excitability and cholinergic modulation in a SAPAP3 mouse model of compulsive motor behavior
JM Malgady, A Baez, ZB Hobel, K Jimenez, J Goldfried… - Cell reports, 2023 - cell.com
Deletion of the obsessive-compulsive disorder (OCD)-associated gene SAP90/PSD-95-
associated protein 3 (Sapap3), which encodes a postsynaptic anchoring protein at …
associated protein 3 (Sapap3), which encodes a postsynaptic anchoring protein at …
Efficacy, tolerability, and safety of toludesvenlafaxine for the treatment of major depressive disorder—A narrative review
O Vasiliu - Pharmaceuticals, 2023 - mdpi.com
The estimated rate of treatment-resistant major depressive disorder (TRD) remains higher
than 30%, even after the discovery of multiple classes of antidepressants in the last 7 …
than 30%, even after the discovery of multiple classes of antidepressants in the last 7 …
Projection-specific deficits in synaptic transmission in adult Sapap3-knockout mice
Obsessive-compulsive disorder (OCD) is a circuit disorder involving corticostriatal
projections, which play a role in motor control. The Sapap3-knockout (KO) mouse is a …
projections, which play a role in motor control. The Sapap3-knockout (KO) mouse is a …
Clinical applications of neurochemical and electrophysiological measurements for closed-loop neurostimulation
The development of closed-loop deep brain stimulation (DBS) systems represents a
significant opportunity for innovation in the clinical application of neurostimulation therapies …
significant opportunity for innovation in the clinical application of neurostimulation therapies …
Norepinephrine and dopamine contribute to distinct repetitive behaviors induced by novel odorant stress in male and female mice
DJ Lustberg, JQ Liu, AF Iannitelli, SO Vanderhoof… - Hormones and …, 2022 - Elsevier
Exposure to unfamiliar odorants induces an array of repetitive defensive and non-defensive
behaviors in rodents which likely reflect adaptive stress responses to the uncertain valence …
behaviors in rodents which likely reflect adaptive stress responses to the uncertain valence …
Neural circuits in goal-directed and habitual behavior: Implications for circuit dysfunction in obsessive-compulsive disorder
LD Simmler, T Ozawa - Neurochemistry international, 2019 - Elsevier
Goal-directed and habitual actions are essential for normal functioning in everyday life. Goal-
directed behaviors are actions that are executed to achieve specific goals. With repetition …
directed behaviors are actions that are executed to achieve specific goals. With repetition …
Disruption of prepulse inhibition is associated with compulsive behavior severity and nucleus accumbens dopamine receptor changes in Sapap3 knockout mice
EE Manning, AY Wang, LM Saikali, AS Winner… - Scientific Reports, 2021 - nature.com
Obsessive compulsive disorder (OCD) is associated with disruption of sensorimotor gating,
which may contribute to difficulties inhibiting intrusive thoughts and compulsive rituals …
which may contribute to difficulties inhibiting intrusive thoughts and compulsive rituals …
Opening new vistas on obsessive-compulsive disorder with the Observing Response Task
L Pickenhan, AL Milton - Cognitive, Affective, & Behavioral Neuroscience, 2024 - Springer
Abstract Obsessive-compulsive disorder (OCD), a highly prevalent and debilitating disorder,
is incompletely understood in terms of underpinning behavioural, psychological, and neural …
is incompletely understood in terms of underpinning behavioural, psychological, and neural …