Development of biosensing platforms plays a key role in research settings for identification
of biomarkers and in clinical applications for diagnostics. Biosensors based on nucleic acids …

Mature microRNAs (miRNAs) are a class of evolutionally conserved, single-stranded, small
(approximately 19− 23 nucleotides), endogenously expressed, and non-protein-coding …

Abstract Background Long non-coding RNAs (lncRNAs) have been implicated in diverse
biological processes. In contrast to extensive genomic annotation of lncRNA transcripts, far …

The ability to quantitate and visualize microRNAs (miRNAs) in situ in single cells would
greatly facilitate the elucidation of miRNA‐mediated regulatory circuits and their disease …

Atomic force microscopy (AFM) allows for nanometer-scale investigation of cells and
molecules. Recent advances have enabled its application in cancer research and diagnosis …

Summary microRNAs regulate developmental cell-fate decisions, tissue homeostasis, and
oncogenesis in distinct ways relative to proteins. Here, we show that the tumor suppressor …

Purpose: Our goal was to identify circulating micro RNA (miRNA) levels that could
distinguish patients with low-stage pancreatic cancer from healthy and disease controls …

Innate immunity constitutes the first line of defence against both external and endogenous
threats in the brain, and microglia cells are considered key mediators of this process. Recent …

Measuring multiple omics profiles from the same single cell opens up the opportunity to
decode molecular regulation that underlies intercellular heterogeneity in development and …

Methods for detecting single nucleic acids in cell and tissues, such as fluorescence in situ
hybridization (FISH), are limited by relatively low signal intensity and nonspecific probe …