In both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G)
complement plays a primary role in disease pathogenesis. Herein we report the outcome of …

Nephritic factors comprise a heterogeneous group of autoantibodies against neoepitopes
generated in the C3 and C5 convertases of the complement system, causing its …

Kidney diseases caused by genetic or acquired dysregulation of the complement alternative
pathway (AP) are traditionally classified on the basis of clinical presentation (atypical …

C3 glomerulonephritis is a clinicopathologic entity defined by the presence of isolated or
dominant deposits of C3 on immunofluorescence. To explore the effect of …

Background Cases reports and small series of patients with C3 glomerulopathy have
reported variable efficacy of eculizumab. Study Design Case series of C3 glomerulopathy …

IgA nephropathy (IgAN) is characterized by a variable clinical course and multifaceted
pathophysiology. There is substantial evidence to suggest that complement activation plays …

Recent advances in our understanding of the disease pathology of membranoproliferative
glomerulonephritis has resulted in its re-classification as complement C3 glomerulopathy …

Abstract Background C3 glomerulopathy (C3G) is a rare, but severe glomerular disease with
grim prognosis. The complex pathogenesis is just unfolding, and involves acquired as well …

C3 glomerulopathy refers to a disease process in which abnormal control of complement
activation, degradation or deposition results in predominant C3 fragment deposition within …

Thrombotic microangiopathy (TMA), characterized by organ injury occurring consequent to
severe endothelial damage, can manifest in a diverse range of diseases. In complement …