Synthesis and antibacterial medicinal evaluation of carbothioamido hydrazonyl thiazolylquinolone with multitargeting antimicrobial potential to combat increasingly …
ZL Zang, YX Wang, N Battini, WW Gao… - European Journal of …, 2024 - Elsevier
The global microbial resistance is a serious threat to human health, and multitargeting
compounds are considered to be promising to combat microbial resistance. In this work, a …
compounds are considered to be promising to combat microbial resistance. In this work, a …
Type IA topoisomerases as targets for infectious disease treatments
Infectious diseases are one of the main causes of death all over the world, with antimicrobial
resistance presenting a great challenge. New antibiotics need to be developed to provide …
resistance presenting a great challenge. New antibiotics need to be developed to provide …
Insights into the DNA and RNA Interactions of Human Topoisomerase III Beta Using Molecular Dynamics Simulations
Y Mamun, YC Tse-Dinh… - Journal of Chemical …, 2024 - ACS Publications
Human topoisomerase III beta (hTOP3B) is the only topoisomerase in the human cell that
can act on both DNA and RNA substrates. Recent findings have emphasized the …
can act on both DNA and RNA substrates. Recent findings have emphasized the …
SPRD: a surface plasmon resonance database of common factors for better experimental planning
PB Tiwari, C Bencheqroun, M Lemus, T Shaw… - BMC molecular and cell …, 2021 - Springer
Background Surface plasmon resonance is a label-free biophysical technique that is widely
used in investigating biomolecular interactions, including protein-protein, protein-DNA, and …
used in investigating biomolecular interactions, including protein-protein, protein-DNA, and …
[HTML][HTML] Small Molecule Inhibitors of Mycobacterium tuberculosis Topoisomerase I Identified by Machine Learning and In Vitro Assays
Tuberculosis (TB) caused by Mycobacterium tuberculosis is a leading infectious cause of
death globally. The treatment of patients becomes much more difficult for the increasingly …
death globally. The treatment of patients becomes much more difficult for the increasingly …
Unraveling topoisomerase IA gate dynamics in presence of PPEF and its preclinical evaluation against multidrug-resistant pathogens
Type IA topoisomerases maintain DNA topology by cleaving ssDNA and relaxing negative
supercoils. The inhibition of its activity in bacteria prevents the relaxation of negative …
supercoils. The inhibition of its activity in bacteria prevents the relaxation of negative …
Structural insights into the repair mechanism of AGT for methyl-induced DNA damage
Methylation induced DNA base-pairing damage is one of the major causes of cancer. O6-
alkylguanine-DNA alkyltransferase (AGT) is considered a demethylation agent of the …
alkylguanine-DNA alkyltransferase (AGT) is considered a demethylation agent of the …
Characterization of molecular interactions between HDAC7 and MEF2A
Interactions of transcriptional corepressors such as histone deacetylase 7 (HDAC7), a class
IIa HDAC, with myocyte enhancer factor-2 (MEF2) regulate MEF2 activity. Despite previous …
IIa HDAC, with myocyte enhancer factor-2 (MEF2) regulate MEF2 activity. Despite previous …
Antimycobacterial, antibiofilm and efflux pump inhibitory activity of extracts from selected Combretum species used in traditional medicine in Zimbabwe
SN Chikafa, CG Fru, S Mukanganyama - Advances in Traditional …, 2024 - Springer
Non-tuberculous mycobacteria infect mostly immunocompromised people. NTM infections
incidence and prevalence increase has led to a public health problem. Combretum species …
incidence and prevalence increase has led to a public health problem. Combretum species …
[HTML][HTML] A Yeast-Based Screening System for Differential Identification of Poisons and Suppressors of Human Topoisomerase I
A Seddek, C Madeira, T Annamalai… - Frontiers in Bioscience …, 2022 - imrpress.com
Background: Inhibition of human topoisomerase I (TOP1) by camptothecin and topotecan
has been shown to reduce excessive transcription of PAMP (Pathogen-Associated …
has been shown to reduce excessive transcription of PAMP (Pathogen-Associated …